{"id":"W2087373536","doi":"10.1016/j.bpj.2008.12.2987","title":"A new role for type 1 ryanodine receptor","year":2009,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"RYR1; Ryanodine receptor; Depolarization; Membrane potential; Chemistry; Biophysics; Extracellular; Malignant hyperthermia; Cell biology; Receptor; Internal medicine; Endocrinology; Biology; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000511714,0.0004181275,0.0005550004,0.0002605894,0.0007116195,0.001365172,0.001180609,0.001277246,0.003359577],"category_scores_gemma":[0.0003911285,0.0001830207,0.0004393608,0.0001401333,0.0009937169,0.002809947,0.0007516354,0.001427293,0.0009457241],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003582124,"about_ca_system_score_gemma":0.0004346377,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001401074,"about_ca_topic_score_gemma":0.0002541787,"domain_scores_codex":[0.9998054,0.00002080872,0.00001117756,0.00007277172,0.00004520662,0.00004473402],"domain_scores_gemma":[0.9997758,0.00005187683,0.00002321016,0.00006129787,0.0000321575,0.00005562292],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005824291,0.00006203897,0.0006653515,0.0003094455,0.00002979008,0.001637808,0.0004112254,0.0003219471,0.8785101,0.07768826,0.006025296,0.03375654],"study_design_scores_gemma":[0.000221262,0.001040041,0.007868219,0.0002130047,0.0001819528,0.01298985,0.001230395,0.005754322,0.3783572,0.1548868,0.4370483,0.0002085031],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6158693,0.1157457,0.1388455,0.04721821,0.009599222,0.000103775,0.0009078048,0.003418683,0.06829174],"genre_scores_gemma":[0.8746932,0.03567405,0.04551046,0.00775889,0.002933223,0.0001147332,0.0007039662,0.0003124955,0.03229907],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003359577,"threshold_uncertainty_score":0.01123893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01709589619483858,"score_gpt":0.2717272728262755,"score_spread":0.2546313766314369,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}