{"id":"W2087393559","doi":"10.1093/cvr/cvq152","title":"HIF-1 inhibition decreases systemic vascular remodelling diseases by promoting apoptosis through a hexokinase 2-dependent mechanism","year":2010,"lang":"en","type":"article","venue":"Cardiovascular Research","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec","funders":"Canadian Institutes of Health Research","keywords":"Cell biology; Vascular remodelling in the embryo; Biology; Apoptosis; Hexokinase; Vascular smooth muscle; Glycolysis; Endocrinology; Growth factor; Internal medicine; Chemistry; Cancer research; Medicine; Biochemistry; Metabolism; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.003343752,0.0003657791,0.000568903,0.0001512572,0.0005811793,0.0001916942,0.0004461588,0.0004114693,0.00003334435],"category_scores_gemma":[0.0008251893,0.0003636282,0.001190584,0.0004001412,0.0002194752,0.00003416974,0.0004061465,0.0007222099,0.00004058537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007264247,"about_ca_system_score_gemma":0.0003043535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004709414,"about_ca_topic_score_gemma":0.00002476819,"domain_scores_codex":[0.9949309,0.0009057564,0.0004339044,0.001223119,0.001550431,0.0009559018],"domain_scores_gemma":[0.9970592,0.00005083642,0.00008502619,0.001728637,0.0006522237,0.0004241386],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006231426,0.0001607309,0.0000451995,0.0002494967,0.0008650061,0.00001343904,0.0001243388,0.0001667829,0.9873105,0.0004340555,0.00219873,0.008369456],"study_design_scores_gemma":[0.001691567,0.0001301798,0.00002315103,0.00015548,0.0003836704,0.0001844757,0.0003601533,0.0002707042,0.8795335,0.0009635052,0.1157173,0.0005863275],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9134397,0.06236909,0.02130078,0.00006291086,0.001029451,0.00125184,0.0001077491,0.00007908648,0.0003594294],"genre_scores_gemma":[0.9845543,0.01057449,0.0006302858,0.00005600452,0.003003672,0.0004044719,0.000417648,0.0001178232,0.000241324],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1135186,"threshold_uncertainty_score":0.9998816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02270066100740331,"score_gpt":0.2859312625699487,"score_spread":0.2632306015625454,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}