{"id":"W2087400628","doi":"10.1021/bi8014828","title":"Large Changes in the CRAC Segment of gp41 of HIV Do Not Destroy Fusion Activity if the Segment Interacts with Cholesterol","year":2008,"lang":"en","type":"article","venue":"Biochemistry","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Gp41; Mutant; Lipid bilayer fusion; Peptide; Peptide sequence; Biochemistry; Membrane; Amino acid; Cholesterol; Fusion; Chemistry; Biology; Biophysics; Cell biology; Antibody; Genetics; Epitope; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000111624,0.0003133415,0.0002719445,0.0001056738,0.0001408733,0.0002196748,0.0002155602,0.0003209916,0.0007203213],"category_scores_gemma":[0.0002438947,0.0001359479,0.0002769362,0.0001173204,0.0003016062,0.0001560911,0.0001541993,0.0006176426,0.0002288549],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001631595,"about_ca_system_score_gemma":0.000162161,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005097123,"about_ca_topic_score_gemma":0.0005750571,"domain_scores_codex":[0.9998429,0.00002350271,0.00001625289,0.00002345171,0.00004516812,0.00004874866],"domain_scores_gemma":[0.9997609,0.00008795184,0.00005139529,0.00004062997,0.00001213102,0.00004696682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008101294,0.00002525313,0.00009194645,0.000009106077,0.000006049819,0.00004869446,0.000009076815,0.0000584692,0.9992439,0.0000219353,0.000006455414,0.0003981506],"study_design_scores_gemma":[0.00001984091,0.0005757787,0.002749787,0.000003532507,0.00001516195,0.0002716926,0.00001730408,0.000400821,0.9953362,0.00001782995,0.0005874897,0.000004532429],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990807,0.0001994797,0.0003113933,0.00002066861,0.000006577909,0.00001010739,0.00005630809,0.00001221252,0.0003026284],"genre_scores_gemma":[0.9981343,0.0001906433,0.0007633166,0.00004569198,0.000005026585,0.00001817966,0.0002349308,0.00001624625,0.0005915802],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007203213,"threshold_uncertainty_score":0.002409697,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01596031011614848,"score_gpt":0.2534234377360682,"score_spread":0.2374631276199198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}