{"id":"W2087400628","doi":"10.1021/bi8014828","title":"Large Changes in the CRAC Segment of gp41 of HIV Do Not Destroy Fusion Activity if the Segment Interacts with Cholesterol","year":2008,"lang":"en","type":"article","venue":"Biochemistry","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Gp41; Mutant; Lipid bilayer fusion; Peptide; Peptide sequence; Biochemistry; Membrane; Amino acid; Cholesterol; Fusion; Chemistry; Biology; Biophysics; Cell biology; Antibody; Genetics; Epitope; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002052404,0.000128176,0.0001707846,0.0000266802,0.00009444908,0.000004479221,0.0002415597,0.00009439485,0.0001105866],"category_scores_gemma":[0.00002906662,0.00006483977,0.00004483926,0.00008227152,0.0002043838,0.00002100333,0.0001008512,0.0002140655,0.00002577827],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004478642,"about_ca_system_score_gemma":0.00006709039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005559641,"about_ca_topic_score_gemma":0.00004506979,"domain_scores_codex":[0.9992226,0.0001206565,0.0001305331,0.0001813123,0.00008952622,0.00025533],"domain_scores_gemma":[0.9993228,0.0001314071,0.0001103102,0.0003780446,0.00003987817,0.00001754716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004805175,0.0008328272,0.01243775,0.00005336812,0.0001012768,0.00001740957,0.001869416,0.000001200137,0.9819739,0.000002570516,0.0008129431,0.001416756],"study_design_scores_gemma":[0.001388467,0.0002352503,0.05231682,0.00007804215,0.00001523602,0.00006450663,0.0008899732,9.281125e-7,0.9441694,6.265519e-7,0.0007824169,0.00005832209],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979846,0.000377402,0.00001225499,0.0009417152,0.00002766804,0.0002378001,0.0001444842,0.000005973257,0.0002680626],"genre_scores_gemma":[0.9991922,0.0001550866,0.00001575217,0.00005245105,0.00001454044,0.00005750416,0.00007935631,0.000005900155,0.000427224],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03987907,"threshold_uncertainty_score":0.2644089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01596031011614848,"score_gpt":0.2534234377360682,"score_spread":0.2374631276199198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}