{"id":"W2087405573","doi":"10.1021/jm3018332","title":"Exploiting an Allosteric Binding Site of PRMT3 Yields Potent and Selective Inhibitors","year":2013,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"National Institute of Mental Health; Canadian Institutes of Health Research; National Institute of General Medical Sciences; Wellcome Trust","keywords":"Chemistry; Allosteric regulation; Binding site; Structure–activity relationship; Stereochemistry; Pharmacology; Biochemistry; Enzyme; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001682183,0.0004077554,0.0003815672,0.0002135405,0.0001740594,0.0002104233,0.0004048136,0.0002273416,0.0009597903],"category_scores_gemma":[0.000155236,0.0001381834,0.0002249502,0.0002283192,0.0002343082,0.0001805745,0.0002912315,0.0005748429,0.0003416753],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003580814,"about_ca_system_score_gemma":0.000288779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005271236,"about_ca_topic_score_gemma":0.001365259,"domain_scores_codex":[0.9998939,0.00001489711,0.000006958446,0.00002270153,0.00002840664,0.00003315696],"domain_scores_gemma":[0.9999658,0.000006204366,0.000009585731,0.000004591956,0.000005473502,0.000008350544],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001947046,0.0001542997,0.0003552721,0.0001592588,0.00002151074,0.0001690456,0.00004538489,0.001619754,0.9775831,0.001120829,0.000465265,0.01811155],"study_design_scores_gemma":[0.0001697229,0.001263884,0.00108321,0.00001267567,0.00003718407,0.0004938396,0.00001757436,0.002343735,0.9836008,0.0002721816,0.01068993,0.00001534586],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9462158,0.01021107,0.03182837,0.0004594987,0.0001199577,0.0002938484,0.0007605312,0.0006542414,0.009456689],"genre_scores_gemma":[0.9859515,0.003619259,0.007517985,0.0001410929,0.00002001835,0.00006378597,0.0004243301,0.00002953296,0.002232505],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009597903,"threshold_uncertainty_score":0.003210783,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006794206481591659,"score_gpt":0.2300537840605679,"score_spread":0.2232595775789762,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}