{"id":"W2087405573","doi":"10.1021/jm3018332","title":"Exploiting an Allosteric Binding Site of PRMT3 Yields Potent and Selective Inhibitors","year":2013,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"National Institute of Mental Health; Canadian Institutes of Health Research; National Institute of General Medical Sciences; Wellcome Trust","keywords":"Chemistry; Allosteric regulation; Binding site; Structure–activity relationship; Stereochemistry; Pharmacology; Biochemistry; Enzyme; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002217275,0.0001087443,0.0001799804,0.00003859984,0.0000326181,0.0000110983,0.00007467315,0.000155502,0.00002591701],"category_scores_gemma":[0.0001020872,0.00009517929,0.00006102215,0.00007882553,0.00006782975,0.00001617922,0.00003939007,0.0001826617,6.544921e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000376455,"about_ca_system_score_gemma":0.00009103095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001333352,"about_ca_topic_score_gemma":0.000001518299,"domain_scores_codex":[0.999106,0.00002333876,0.00037254,0.00013602,0.0002272571,0.0001347699],"domain_scores_gemma":[0.9990566,0.00001323086,0.0004407791,0.0001027965,0.0002538718,0.000132665],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006592238,0.00002678152,0.002216281,0.00006116686,0.00005502848,0.000003480896,0.0001487635,0.00006964963,0.989746,1.046402e-7,0.0006946984,0.006912175],"study_design_scores_gemma":[0.0006108113,0.000459645,0.004099778,0.0001972957,0.00005140079,0.0004701006,0.0006021023,0.00009657637,0.9929425,0.00001455497,0.0003535249,0.0001017738],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978244,0.001322425,0.0002647744,0.0001921132,0.00009705547,0.00006208329,0.000002226823,0.000002412722,0.0002325237],"genre_scores_gemma":[0.9984695,0.0002221182,0.0003785336,0.00003114256,0.0007734583,0.0000021593,0.00001416765,0.000013019,0.00009585112],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006810401,"threshold_uncertainty_score":0.3881299,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006794206481591659,"score_gpt":0.2300537840605679,"score_spread":0.2232595775789762,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}