{"id":"W2087414338","doi":"10.1038/emboj.2009.361","title":"Increased skeletal VEGF enhances β‐catenin activity and results in excessively ossified bones","year":2009,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":207,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"KU Leuven; Fonds Wetenschappelijk Onderzoek","keywords":"Biology; Vascular endothelial growth factor; Endocrinology; GSK-3; Internal medicine; Beta-catenin; Bone marrow; Angiogenesis; GSK3B; Anabolism; Cancer research; Cell biology; Signal transduction; Wnt signaling pathway; Immunology; VEGF receptors; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003193585,0.0004837942,0.0004994317,0.000769869,0.0002689291,0.0006394796,0.0003883729,0.0007941092,0.00341929],"category_scores_gemma":[0.0003158561,0.0004532751,0.0004539884,0.0003165193,0.0007782562,0.0004323449,0.0004120289,0.00130463,0.0006711042],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007396713,"about_ca_system_score_gemma":0.0004379018,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001256303,"about_ca_topic_score_gemma":0.002109845,"domain_scores_codex":[0.9993575,0.00009051942,0.00007129155,0.0001139168,0.0002007453,0.0001660697],"domain_scores_gemma":[0.999364,0.0001024412,0.0001926866,0.00005971743,0.00002983809,0.0002515028],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002532241,0.00005346118,0.0002276487,0.00003000611,0.000007949343,0.0002536773,0.000009178022,0.00008959691,0.9976594,0.0003581068,0.00005573028,0.001002],"study_design_scores_gemma":[0.00004013951,0.0002811026,0.003840124,0.000005585639,0.00002432744,0.001078948,0.00003908975,0.0007455635,0.9920179,0.000128242,0.001792966,0.000006070722],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917837,0.002007854,0.003199641,0.0002605251,0.00008877022,0.00002751726,0.0004261109,0.0002237642,0.001982021],"genre_scores_gemma":[0.9932696,0.0005326141,0.001454176,0.00005807541,0.0000245734,0.00002350535,0.0002524216,0.00004787506,0.004337118],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00341929,"threshold_uncertainty_score":0.01143861,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01233583611334899,"score_gpt":0.2588699713707519,"score_spread":0.2465341352574029,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}