{"id":"W2087414338","doi":"10.1038/emboj.2009.361","title":"Increased skeletal VEGF enhances β‐catenin activity and results in excessively ossified bones","year":2009,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":207,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"KU Leuven; Fonds Wetenschappelijk Onderzoek","keywords":"Biology; Vascular endothelial growth factor; Endocrinology; GSK-3; Internal medicine; Beta-catenin; Bone marrow; Angiogenesis; GSK3B; Anabolism; Cancer research; Cell biology; Signal transduction; Wnt signaling pathway; Immunology; VEGF receptors; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006650622,0.0001337716,0.0001366214,0.00004307262,0.0001715052,0.00007138345,0.0002064517,0.00007522515,0.0000122331],"category_scores_gemma":[0.00008951891,0.00009031672,0.00004718308,0.00008785788,0.00008695052,0.00001133287,0.00004141847,0.0002186125,0.000003079305],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001569887,"about_ca_system_score_gemma":0.00009586524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002222736,"about_ca_topic_score_gemma":0.00002379464,"domain_scores_codex":[0.9990689,0.0001183563,0.0002404283,0.000192263,0.0001491354,0.0002309295],"domain_scores_gemma":[0.9995748,0.00002213241,0.0001709798,0.0001119941,0.00005060388,0.000069509],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006280148,0.00004493705,0.0005752309,0.000003307729,0.00002883663,0.0000187468,0.000261274,0.00001348489,0.9758636,0.0000113887,0.001287923,0.02126327],"study_design_scores_gemma":[0.001938306,0.0003110391,0.1997318,0.00005886305,0.0000198562,0.0002223294,0.0001442737,0.00004024812,0.7931346,0.001182757,0.002933463,0.0002825355],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959928,0.001280308,0.0001138954,0.001254394,0.0001259081,0.00006662175,0.000003213356,0.000005827958,0.00115697],"genre_scores_gemma":[0.9982749,0.0005466248,0.0001797213,0.0002123894,0.0003761968,0.000004009235,0.000005631188,0.000007445177,0.0003930362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1991566,"threshold_uncertainty_score":0.3683009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01233583611334899,"score_gpt":0.2588699713707519,"score_spread":0.2465341352574029,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}