{"id":"W2087415918","doi":"10.1186/1471-2180-8-149","title":"Cinnamaldehyde and cinnamaldehyde derivatives reduce virulence in Vibrio spp. by decreasing the DNA-binding activity of the quorum sensing response regulator LuxR","year":2008,"lang":"en","type":"article","venue":"BMC Microbiology","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":313,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Vlaamse regering; Fonds Wetenschappelijk Onderzoek","keywords":"Vibrio harveyi; Quorum sensing; Virulence; Microbiology; Biology; Biofilm; Vibrio; Vibrio vulnificus; Vibrio Infections; Cinnamaldehyde; Biochemistry; Bacteria; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009263775,0.000529205,0.0001838666,0.0002811701,0.0001093089,0.0002135637,0.0002877059,0.0003224184,0.001775254],"category_scores_gemma":[0.000187757,0.00009515649,0.0002937067,0.0001794674,0.0001511194,0.0001811434,0.0001281047,0.000340431,0.0001786511],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003124126,"about_ca_system_score_gemma":0.000250433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002010552,"about_ca_topic_score_gemma":0.004041264,"domain_scores_codex":[0.9998915,0.00001502913,0.000009508379,0.00001627031,0.00004141437,0.0000262543],"domain_scores_gemma":[0.9998951,0.00002181531,0.00002874764,0.000009420823,0.00002898847,0.00001595578],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001115175,0.00003854714,0.0001416545,0.00007948217,0.00001081833,0.00002792349,0.000005892545,0.000108707,0.9980868,0.00002299872,0.00002092804,0.001344762],"study_design_scores_gemma":[0.00001525421,0.0009089457,0.003908971,0.00001139771,0.00003927599,0.00009573241,0.00001829751,0.000292114,0.9933042,0.00002228909,0.001376527,0.000006949046],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897444,0.006101008,0.001448066,0.0001419295,0.00004424924,0.00004731152,0.0004185137,0.00007168496,0.001982903],"genre_scores_gemma":[0.9935079,0.002102639,0.002068446,0.0001036199,0.000009436707,0.0000232786,0.00041115,0.00001233962,0.001761226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002010552,"threshold_uncertainty_score":0.005938828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01240975120952296,"score_gpt":0.2245522525488114,"score_spread":0.2121425013392885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}