{"id":"W2087443316","doi":"10.1128/jb.02016-12","title":"2-Nitrobenzoate 2-Nitroreductase (NbaA) Switches Its Substrate Specificity from 2-Nitrobenzoic Acid to 2,4-Dinitrobenzoic Acid under Oxidizing Conditions","year":2012,"lang":"en","type":"article","venue":"Journal of Bacteriology","topic":"Amino Acid Enzymes and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; National Research Council Canada; Biotechnology Research Institute; Centre in Green Chemistry and Catalysis","funders":"","keywords":"Nitroreductase; Cysteine; Dithiothreitol; Stereochemistry; Enzyme; Biochemistry; Biology; Dithionite; Thiol; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009570715,0.0004706595,0.0003526541,0.0001214739,0.0001059123,0.0002210789,0.0002739538,0.0002403771,0.0004010058],"category_scores_gemma":[0.0001486021,0.0001746909,0.0001922,0.000127703,0.000217803,0.0001783755,0.0002502538,0.0003299413,0.000267059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003339247,"about_ca_system_score_gemma":0.0002434194,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002191572,"about_ca_topic_score_gemma":0.001832863,"domain_scores_codex":[0.9997724,0.00002185384,0.00001413248,0.00006072258,0.0000787034,0.00005227789],"domain_scores_gemma":[0.9999259,0.000009552951,0.00002036708,0.000009655186,0.00001398397,0.00002065314],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001261426,0.000006697034,0.00009598023,0.000005083109,0.000001004104,0.00001110128,0.000004765222,0.00001254666,0.9995302,0.00001067838,0.000005247756,0.0003040907],"study_design_scores_gemma":[0.000002510885,0.00006492205,0.00197291,0.00000166161,0.000003670652,0.0001413722,0.00001914845,0.0004575135,0.9966785,0.00001395083,0.0006402705,0.000003640305],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964854,0.0003590853,0.002313094,0.00004734146,0.00001604491,0.00001334339,0.00009316723,0.0001186448,0.0005540068],"genre_scores_gemma":[0.9958227,0.0002546217,0.002307277,0.00002580676,0.000004549762,0.00001453712,0.0003154217,0.00002721879,0.001227942],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002191572,"threshold_uncertainty_score":0.004357576,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02435528801755846,"score_gpt":0.2692840632371882,"score_spread":0.2449287752196297,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}