{"id":"W2087495866","doi":"10.1038/sj.cdd.4401890","title":"TIR, CARD and PYRIN: three domains for an antimicrobial triad","year":2006,"lang":"en","type":"review","venue":"Cell Death and Differentiation","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":151,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Pyrin domain; Innate immune system; NOD2; Cell biology; Inflammasome; Biology; NOD1; NALP3; G protein-coupled receptor; Receptor; Intracellular; Signal transduction; Nod; TLR4; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001892324,0.0003586645,0.0008975653,0.0002038523,0.0002708983,0.00007534999,0.0001038132,0.0006504273,0.00001733089],"category_scores_gemma":[0.00001958293,0.000293023,0.0002100389,0.00005654315,0.00005912522,0.0001357799,0.00004966515,0.0001947326,0.00002742185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003360054,"about_ca_system_score_gemma":0.00006962443,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000469773,"about_ca_topic_score_gemma":0.00003350331,"domain_scores_codex":[0.9985849,0.0001982325,0.0004898285,0.0004067792,0.00002677772,0.000293505],"domain_scores_gemma":[0.9992198,0.0001494809,0.0003197888,0.0002374125,0.00004617013,0.00002733506],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002294135,0.0001409439,0.00009409088,0.006473108,0.0002092601,0.000001090905,0.0000863612,2.06876e-7,0.00547757,0.0007870419,0.001895888,0.984605],"study_design_scores_gemma":[0.002396156,0.0002909759,0.0008613347,0.0007051179,0.001402798,0.00003754515,0.000007322667,0.00001447506,0.001936804,0.0001965537,0.9916551,0.0004958658],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0225918,0.9736376,0.001513314,0.000007146344,0.0005734096,0.001207868,0.0001110674,0.00005282791,0.0003049653],"genre_scores_gemma":[0.005020373,0.9864197,0.00007400657,0.00001316645,0.0001413908,0.0001039091,0.006915745,0.00004096051,0.001270751],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9897591,"threshold_uncertainty_score":0.9999522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03366502483937963,"score_gpt":0.278256293776886,"score_spread":0.2445912689375064,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}