{"id":"W2087554245","doi":"10.1038/cdd.2011.171","title":"Inhibition of Notch3 signalling induces rhabdomyosarcoma cell differentiation promoting p38 phosphorylation and p21Cip1 expression and hampers tumour cell growth in vitro and in vivo","year":2011,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Sarcoma Diagnosis and Treatment","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Associazione Italiana per la Ricerca sul Cancro; Ministero dell’Istruzione, dell’Università e della Ricerca; Ministero della Salute","keywords":"Cell biology; In vivo; Phosphorylation; In vitro; Cell growth; Chemistry; p38 mitogen-activated protein kinases; Cancer research; Cell; Biology; MAPK/ERK pathway; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001546336,0.000229932,0.0003439508,0.0003062394,0.00008080138,0.00003736185,0.00002119716,0.0001474741,0.00001533996],"category_scores_gemma":[0.00002173505,0.000201231,0.00003250393,0.0001169046,0.00003794843,0.0002428518,0.00004956701,0.0001387692,3.328754e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004382986,"about_ca_system_score_gemma":0.00001652259,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002098781,"about_ca_topic_score_gemma":0.00002456817,"domain_scores_codex":[0.998709,0.00008297123,0.0004168987,0.0004020643,0.0001785725,0.0002105032],"domain_scores_gemma":[0.9994038,0.00009734455,0.0002451736,0.00007931201,0.00005358928,0.0001207789],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002051103,0.0004760117,0.3904376,0.0003706304,0.000004355499,0.000006065112,0.002876273,3.947722e-7,0.6046472,0.00001082344,8.597066e-7,0.0009647125],"study_design_scores_gemma":[0.002333948,0.0001121081,0.447942,0.0002126142,0.00005732443,0.000002432012,0.000311816,0.001336002,0.5473743,0.0002191615,1.879278e-7,0.00009810607],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996935,0.001973717,0.0001856222,0.00002583491,0.00003557269,0.0005977851,0.000008500841,0.000017424,0.0002205293],"genre_scores_gemma":[0.998082,0.001036373,0.0006861615,0.00001812618,0.00002147684,0.00004470718,0.0000808887,0.00002009804,0.0000101802],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05750436,"threshold_uncertainty_score":0.8205961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01809248029938246,"score_gpt":0.214544988265861,"score_spread":0.1964525079664786,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}