{"id":"W2087570918","doi":"10.1042/bj20061216","title":"<i>In vitro</i> selection and characterization of RNA aptamers binding thyroxine hormone","year":2007,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Génome Québec; Université de Sherbrooke","keywords":"Systematic evolution of ligands by exponential enrichment; Aptamer; RNA; Riboswitch; Ribozyme; G-quadruplex; Biology; Biochemistry; Binding selectivity; Binding site; Chemistry; Non-coding RNA; Computational biology; DNA; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004134688,0.00008797536,0.0001108996,0.00007525596,0.00003657185,0.00001298081,0.00006649394,0.0001372292,0.000007358404],"category_scores_gemma":[0.00004325188,0.00008102574,0.00004322145,0.00009711745,0.00002953135,0.000007062817,0.00002611103,0.00009771188,9.204502e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001432062,"about_ca_system_score_gemma":0.0000195321,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001833751,"about_ca_topic_score_gemma":3.262198e-7,"domain_scores_codex":[0.9993156,0.00002636013,0.0002420088,0.0001363589,0.0001069378,0.0001727527],"domain_scores_gemma":[0.9996767,0.000008130325,0.0001329462,0.00005797343,0.00004365975,0.00008060643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003279925,0.00002958401,0.0000778736,0.000005259471,0.00001339509,0.00000271155,0.00001392471,1.114735e-7,0.9944827,0.00000867167,0.00005402329,0.004983755],"study_design_scores_gemma":[0.0003820167,0.0001157062,0.0006890905,0.00001193456,0.000007580889,0.0001112471,0.00001813596,0.000007998142,0.9976915,0.00003220671,0.0008414406,0.0000911628],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937013,0.000300995,0.005689524,0.00009176438,0.00007643238,0.00006392862,0.000004145729,0.000002693349,0.0000692473],"genre_scores_gemma":[0.9974973,0.0004478077,0.001613683,0.00007516321,0.0002754239,0.000001432366,0.00001925281,0.00001098582,0.00005901381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004892592,"threshold_uncertainty_score":0.3304134,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006088570550613139,"score_gpt":0.2238721681431266,"score_spread":0.2177835975925135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}