{"id":"W2087592651","doi":"10.1016/s0049-3848(00)00333-9","title":"In Vitro and in Vivo Properties of Bicyclic Lactam Inhibitors","year":2000,"lang":"en","type":"article","venue":"Thrombosis Research","topic":"Blood Coagulation and Thrombosis Mechanisms","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"BioPhage Pharma (Canada); Armand Frappier Museum","funders":"","keywords":"Thrombin; In vivo; Antithrombotic; Bicyclic molecule; Pharmacology; Chemistry; Discovery and development of direct thrombin inhibitors; Plasmin; Thrombin time; Lactam; In vitro; Coagulation; Medicine; Biochemistry; Platelet; Immunology; Partial thromboplastin time; Stereochemistry; Internal medicine; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003755259,0.0003531442,0.0003879376,0.0002750265,0.0001723734,0.0003278455,0.0002550764,0.0002602093,0.001981818],"category_scores_gemma":[0.0006925371,0.0001789107,0.0001740994,0.0002472397,0.0001949609,0.0002115317,0.000106749,0.0006220473,0.0003970514],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003219368,"about_ca_system_score_gemma":0.0001713459,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001202579,"about_ca_topic_score_gemma":0.001079745,"domain_scores_codex":[0.9997069,0.0001250638,0.00001768374,0.00001945182,0.00005701043,0.00007396387],"domain_scores_gemma":[0.9996039,0.0001717414,0.000076223,0.000032296,0.00003478771,0.00008101045],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009380333,0.0004476997,0.0007760748,0.0001808989,0.0000577608,0.0001427884,0.00007750825,0.0007479245,0.9731269,0.0002061589,0.0005164359,0.01433944],"study_design_scores_gemma":[0.0003657378,0.014458,0.01015774,0.00002851289,0.0001716847,0.0006481864,0.00005982884,0.001901892,0.9659107,0.00009937578,0.006176111,0.00002224365],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9750636,0.02004548,0.001204988,0.0001704454,0.00007564817,0.0000240593,0.0006082125,0.0000549426,0.002752555],"genre_scores_gemma":[0.9921153,0.004523106,0.0004609918,0.00007215306,0.00006068774,0.00002347038,0.00088821,0.00001550858,0.001840516],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001981818,"threshold_uncertainty_score":0.006629884,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1021923139536195,"score_gpt":0.3687332881894503,"score_spread":0.2665409742358308,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}