{"id":"W2087596395","doi":"10.1021/bi0492760","title":"Hydrophobic Helical Hairpins:  Design and Packing Interactions in Membrane Environments","year":2004,"lang":"en","type":"article","venue":"Biochemistry","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Antiparallel (mathematics); Chemistry; Helix (gastropod); Dimer; Crystallography; Transmembrane domain; Helix bundle; Circular dichroism; Hydrogen bond; Stereochemistry; Transmembrane protein; Folding (DSP implementation); Side chain; Protein structure; Mutagenesis; Membrane; Mutant; Molecule; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003163724,0.0002100004,0.0002433412,0.0001550927,0.0002631583,0.0004209394,0.0003638021,0.0002724334,0.0005561165],"category_scores_gemma":[0.0002799618,0.0002312675,0.0001860946,0.0001301276,0.0002501336,0.0003794683,0.0002523967,0.0004279593,0.0003322765],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002391153,"about_ca_system_score_gemma":0.0001640312,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001218563,"about_ca_topic_score_gemma":0.0002542053,"domain_scores_codex":[0.9998754,0.0000373329,0.000009433557,0.00002349797,0.00002964246,0.00002460268],"domain_scores_gemma":[0.9998606,0.00002853208,0.00003002171,0.00001118116,0.0000215059,0.0000481677],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009743726,0.00005578839,0.0005745228,0.00005360923,0.000007104456,0.0001348869,0.00007498426,0.002623242,0.9890376,0.001660713,0.00005955698,0.005620686],"study_design_scores_gemma":[0.00007688574,0.002114384,0.002708569,0.00003100599,0.00004665643,0.0005829846,0.0001537434,0.03356989,0.9499631,0.002140088,0.008578452,0.00003427906],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9616532,0.0006403233,0.03596591,0.00006746364,0.00001784561,0.0001310216,0.00006399847,0.0002364438,0.001223599],"genre_scores_gemma":[0.9655263,0.0004292576,0.03279051,0.00005334039,0.00001422798,0.00009054911,0.0001227581,0.00003372845,0.0009392682],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005561165,"threshold_uncertainty_score":0.00186038,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01230957914230511,"score_gpt":0.2522222212840369,"score_spread":0.2399126421417318,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}