{"id":"W2087596395","doi":"10.1021/bi0492760","title":"Hydrophobic Helical Hairpins:  Design and Packing Interactions in Membrane Environments","year":2004,"lang":"en","type":"article","venue":"Biochemistry","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Antiparallel (mathematics); Chemistry; Helix (gastropod); Dimer; Crystallography; Transmembrane domain; Helix bundle; Circular dichroism; Hydrogen bond; Stereochemistry; Transmembrane protein; Folding (DSP implementation); Side chain; Protein structure; Mutagenesis; Membrane; Mutant; Molecule; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006538758,0.000160897,0.0001182534,0.00002673434,0.00005020028,0.00001946828,0.0001084557,0.0001230113,0.00002196694],"category_scores_gemma":[0.0000249383,0.0001578046,0.00004612701,0.00005354447,0.00008586222,0.000005109231,0.00007971336,0.0001301031,0.000007730384],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003806729,"about_ca_system_score_gemma":0.00004978387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001955162,"about_ca_topic_score_gemma":0.000006927272,"domain_scores_codex":[0.999146,0.00001830193,0.0001654978,0.0003692677,0.00008962147,0.0002112652],"domain_scores_gemma":[0.9996024,0.000006429349,0.00004228278,0.0002511507,0.000006993268,0.00009076309],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004050388,0.00006545219,0.0004747304,0.00001749499,0.00001113199,0.00001124101,0.0000247835,0.00009497895,0.9987742,0.000002973953,0.00003163475,0.0004508896],"study_design_scores_gemma":[0.0007968596,0.00004300134,0.0009855023,0.00003156847,0.00001398228,0.00009075061,0.00003954208,0.000009766269,0.9957623,0.00001796447,0.002025707,0.0001830523],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985239,0.0002087393,0.0007022639,0.0001174987,0.00009534953,0.0001272082,0.000006265359,0.000009683167,0.0002090878],"genre_scores_gemma":[0.9978103,0.0001534314,0.001210161,0.0001491017,0.0001940896,0.00002600235,0.00006311257,0.00001861721,0.0003751697],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003011882,"threshold_uncertainty_score":0.6435084,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01230957914230511,"score_gpt":0.2522222212840369,"score_spread":0.2399126421417318,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}