{"id":"W2087651356","doi":"10.1093/nar/gni094","title":"Single nucleotide extension technology for quantitative site-specific evaluation of metC/C in GC-rich regions","year":2005,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Addiction and Mental Health","funders":"Canadian Psychiatric Research Foundation; National Alliance for Research on Schizophrenia and Depression","keywords":"Cytosine; Biology; Primer extension; Bisulfite; Genotyping; DNA; Snapshot (computer storage); DNA methylation; Genetics; Primer (cosmetics); Computational biology; DNA sequencer; Bisulfite sequencing; Nucleotide; Molecular biology; DNA sequencing; Genotype; Base sequence; Gene; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002533235,0.0001115817,0.0001702669,0.0004566775,0.0001122834,0.00001756622,0.0002096845,0.0002522391,0.00003465509],"category_scores_gemma":[0.001054584,0.0001127591,0.00006130935,0.00058292,0.0002137384,0.00000784017,0.0001268482,0.0001791976,0.00002065934],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009906926,"about_ca_system_score_gemma":0.0001097681,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001373357,"about_ca_topic_score_gemma":0.0002001998,"domain_scores_codex":[0.9980461,0.0002981486,0.0003310046,0.0004412255,0.0005312492,0.0003522816],"domain_scores_gemma":[0.9979156,0.0001169612,0.0000878947,0.0004669781,0.001360729,0.00005183881],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001299336,0.0001974653,0.001130419,0.00001077758,0.00001321505,3.987032e-7,0.0001767248,0.0004371502,0.9615797,0.00124295,0.0006573121,0.03442395],"study_design_scores_gemma":[0.001189785,0.001014234,0.00322414,0.00003128312,0.00001452665,0.000001015102,0.0006143294,0.004612764,0.9239054,0.005137209,0.06009734,0.0001580025],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906279,0.004345008,0.001915027,0.0008449548,0.00005506035,0.0006940434,0.00001483532,0.00000958593,0.001493559],"genre_scores_gemma":[0.9861785,0.0006690081,0.01264681,0.00001239547,0.0001142183,0.00008821343,0.0000773892,0.00002971297,0.0001838162],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05944003,"threshold_uncertainty_score":0.4598183,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1378757329154448,"score_gpt":0.4090809978525818,"score_spread":0.271205264937137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}