{"id":"W2087651356","doi":"10.1093/nar/gni094","title":"Single nucleotide extension technology for quantitative site-specific evaluation of metC/C in GC-rich regions","year":2005,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Addiction and Mental Health","funders":"Canadian Psychiatric Research Foundation; National Alliance for Research on Schizophrenia and Depression","keywords":"Cytosine; Biology; Primer extension; Bisulfite; Genotyping; DNA; Snapshot (computer storage); DNA methylation; Genetics; Primer (cosmetics); Computational biology; DNA sequencer; Bisulfite sequencing; Nucleotide; Molecular biology; DNA sequencing; Genotype; Base sequence; Gene; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002634454,0.001429108,0.001335312,0.001699357,0.0004884052,0.0007638519,0.0009672541,0.001223108,0.001718273],"category_scores_gemma":[0.003808613,0.0009632486,0.0008504721,0.001393647,0.0006861545,0.0006583416,0.0006603965,0.002319783,0.00121085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004456248,"about_ca_system_score_gemma":0.000840458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006383492,"about_ca_topic_score_gemma":0.002337917,"domain_scores_codex":[0.9973501,0.001004824,0.0001997209,0.0008134999,0.0005143324,0.0001175506],"domain_scores_gemma":[0.9975659,0.001126348,0.000386945,0.0003516183,0.0004341302,0.0001350067],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001005939,0.00003254095,0.0003974857,0.000217407,0.00002754639,0.00003446098,0.00009184257,0.0002238902,0.9923803,0.0002375131,0.00005059647,0.00620595],"study_design_scores_gemma":[0.00001595843,0.0004724019,0.004009617,0.00004526958,0.00009243577,0.0002447797,0.00004004807,0.004705055,0.985796,0.0003148962,0.004219766,0.0000436529],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.1796889,0.005686257,0.8076617,0.000115961,0.0002125483,0.0007910213,0.001929613,0.001807391,0.002106674],"genre_scores_gemma":[0.1413129,0.003763614,0.8477764,0.0001933508,0.00004070372,0.001498625,0.00214102,0.0001731348,0.003100175],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002634454,"threshold_uncertainty_score":0.01393247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1378757329154448,"score_gpt":0.4090809978525818,"score_spread":0.271205264937137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}