{"id":"W2087668609","doi":"10.1128/jvi.01738-10","title":"Structure-Based Analysis of the Interaction between the Simian Virus 40 T-Antigen Origin Binding Domain and Single-Stranded DNA","year":2010,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Polyomavirus and related diseases","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Biology; DNA; Oligonucleotide; DNA replication; Molecular biology; HMG-box; Binding domain; Binding site; Mutant; DNA-binding protein; Crystallography; Genetics; Gene; Chemistry; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001462977,0.000407971,0.0004307016,0.0002153059,0.0004480759,0.0002739924,0.0005471274,0.0004089076,0.0009212567],"category_scores_gemma":[0.0002970358,0.0001699464,0.0003801673,0.0002499324,0.0002390052,0.0002734324,0.0001619158,0.00071404,0.0002344839],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001034712,"about_ca_system_score_gemma":0.0003970974,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003293789,"about_ca_topic_score_gemma":0.0035059,"domain_scores_codex":[0.9998795,0.00002207449,0.000006284711,0.00002073669,0.00005267853,0.00001871534],"domain_scores_gemma":[0.999898,0.00003110143,0.00002212215,0.000007816925,0.00001560932,0.00002534859],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004722076,0.0004461977,0.00298992,0.0001508825,0.00005066727,0.0003849659,0.00008033293,0.004214782,0.9873528,0.0009724132,0.0002896273,0.002595214],"study_design_scores_gemma":[0.0001787004,0.000971203,0.02730999,0.00003103547,0.0001254316,0.001162467,0.0002063545,0.0752333,0.8882478,0.0004104709,0.006088139,0.00003495304],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974723,0.0005975611,0.001075208,0.00008586661,0.00001037058,0.00001442823,0.0001426262,0.00002932,0.0005723515],"genre_scores_gemma":[0.9928404,0.0005207285,0.00463391,0.00004789373,0.000006768629,0.00001450083,0.001031391,0.00001163537,0.0008927036],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003293789,"threshold_uncertainty_score":0.007507384,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01811139414298365,"score_gpt":0.2948857151241832,"score_spread":0.2767743209811996,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}