{"id":"W2087698610","doi":"10.1007/s00726-012-1450-4","title":"4-[18F]Fluoro-N-methyl-N-(propyl-2-yn-1-yl)benzenesulfonamide ([18F]F-SA): a versatile building block for labeling of peptides, proteins and oligonucleotides with fluorine-18 via Cu(I)-mediated click chemistry","year":2013,"lang":"en","type":"article","venue":"Amino Acids","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Bioconjugation; Chemistry; Click chemistry; Oligonucleotide; Combinatorial chemistry; Radiosynthesis; Sulfonamide; Lipophilicity; Stereochemistry; Biochemistry; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003742386,0.0007133594,0.0003744612,0.00032216,0.0001880748,0.0002265901,0.0006010163,0.0005899865,0.001203488],"category_scores_gemma":[0.0001746462,0.0002791721,0.0001598877,0.0001914709,0.000277721,0.0003878494,0.0002402041,0.0004572483,0.000716277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004241847,"about_ca_system_score_gemma":0.0003342082,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008861874,"about_ca_topic_score_gemma":0.001440862,"domain_scores_codex":[0.9998261,0.00003668982,0.000007263112,0.00004608654,0.00003225448,0.00005155613],"domain_scores_gemma":[0.999916,0.00001865222,0.00002450088,0.000006006014,0.000009056409,0.00002578148],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001813525,0.0000217503,0.00009117725,0.00004696026,0.000006160709,0.0001281237,0.00001342178,0.0001293973,0.9955437,0.0002755994,0.0002209643,0.003341427],"study_design_scores_gemma":[0.00003411506,0.000355382,0.0006881665,0.000002626522,0.00001218196,0.0006172466,0.000004248046,0.0006936727,0.992053,0.00003907102,0.00548941,0.00001091753],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.8844533,0.007468266,0.09464604,0.0004457749,0.0001743841,0.0001644365,0.0009024006,0.001810779,0.009934643],"genre_scores_gemma":[0.9439837,0.002269801,0.04761765,0.0001121298,0.00007694552,0.0001529982,0.0007382397,0.00006442837,0.004984097],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.001203488,"threshold_uncertainty_score":0.004026055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01123583679638706,"score_gpt":0.2348039305525098,"score_spread":0.2235680937561227,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}