{"id":"W2087699799","doi":"10.1038/ncomms6522","title":"Small RNA changes en route to distinct cellular states of induced pluripotency","year":2014,"lang":"en","type":"article","venue":"Nature Communications","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Institute of Infection and Immunity; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"National Medical Research Council; Cancer Council NSW; National Health and Medical Research Council; College of Medicine, Seoul National University; Canadian Institutes of Health Research; Tour de Cure; Australian Research Council; Ministry of Knowledge Economy; Medical Research Council; Stem Cell Network","keywords":"Reprogramming; Induced pluripotent stem cell; Biology; microRNA; Epigenetics; Embryonic stem cell; Somatic cell; DNA methylation; Histone; Transcription (linguistics); Computational biology; Cell biology; Genetics; Gene expression; Cell; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004197899,0.0001336712,0.000155397,0.00009139687,0.0001209266,0.00001695911,0.001458092,0.0002889156,0.000008011581],"category_scores_gemma":[0.000436744,0.0001265931,0.00006304479,0.0002037756,0.00007233625,0.000002503171,0.0009293264,0.0004263415,0.00001846814],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002161733,"about_ca_system_score_gemma":0.00005319088,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007055234,"about_ca_topic_score_gemma":0.001280574,"domain_scores_codex":[0.998893,0.0002801991,0.0001871284,0.0002445985,0.0001663205,0.0002287594],"domain_scores_gemma":[0.9974965,0.0001001733,0.00008515509,0.001966669,0.0002364753,0.0001150547],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001878362,0.00008821045,0.001118504,0.00002105514,0.00003791267,2.923002e-7,0.0001218216,0.00001139548,0.9927052,0.0005466618,0.0008482315,0.0044819],"study_design_scores_gemma":[0.0002972166,0.0002855612,0.008986721,0.00003162292,0.00002202003,0.000002080762,0.0000662625,0.0003371542,0.7451736,0.0001379352,0.2444361,0.0002237094],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9805074,0.003287686,0.00200802,0.007250689,0.0001149421,0.0004629736,0.00009825014,0.00002711601,0.006242914],"genre_scores_gemma":[0.9936833,0.0005208494,0.004187516,0.0002691592,0.00008627686,0.0000501102,0.0005581637,0.00002389789,0.0006207248],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2475316,"threshold_uncertainty_score":0.5162316,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02434161003129464,"score_gpt":0.292087347318263,"score_spread":0.2677457372869684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}