{"id":"W2087699799","doi":"10.1038/ncomms6522","title":"Small RNA changes en route to distinct cellular states of induced pluripotency","year":2014,"lang":"en","type":"article","venue":"Nature Communications","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Institute of Infection and Immunity; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"National Medical Research Council; Cancer Council NSW; National Health and Medical Research Council; College of Medicine, Seoul National University; Canadian Institutes of Health Research; Tour de Cure; Australian Research Council; Ministry of Knowledge Economy; Medical Research Council; Stem Cell Network","keywords":"Reprogramming; Induced pluripotent stem cell; Biology; microRNA; Epigenetics; Embryonic stem cell; Somatic cell; DNA methylation; Histone; Transcription (linguistics); Computational biology; Cell biology; Genetics; Gene expression; Cell; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000272228,0.0002190509,0.000193155,0.0003220786,0.0002253003,0.0009472851,0.0002400306,0.0004361309,0.002586899],"category_scores_gemma":[0.0005105982,0.0002408171,0.0003965929,0.00015867,0.0003743946,0.0005644705,0.0003106286,0.0008290456,0.0005885886],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003937195,"about_ca_system_score_gemma":0.0001514662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001558439,"about_ca_topic_score_gemma":0.0003600701,"domain_scores_codex":[0.9997925,0.00003653385,0.00001758534,0.00006526721,0.00005366119,0.00003439537],"domain_scores_gemma":[0.9997119,0.0001077909,0.0000571219,0.00004898137,0.00003164623,0.0000424349],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008751525,0.000007650519,0.0001259056,0.00001693114,0.000005448545,0.00005819751,0.00002617445,0.00006733039,0.9955117,0.002099162,0.00004751202,0.001946481],"study_design_scores_gemma":[0.00001781236,0.0001360076,0.003599751,0.000006800457,0.00001716606,0.0001531181,0.00005668385,0.0006008368,0.9913512,0.0008448314,0.00320699,0.000008714397],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.962303,0.002501212,0.0201219,0.0004926912,0.0003595326,0.00005401649,0.0005843783,0.000504225,0.01307911],"genre_scores_gemma":[0.9923873,0.0005446207,0.00254042,0.000177986,0.00003694027,0.00003481564,0.0003296007,0.0001258261,0.003822625],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002586899,"threshold_uncertainty_score":0.008654058,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02434161003129464,"score_gpt":0.292087347318263,"score_spread":0.2677457372869684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}