{"id":"W2087728192","doi":"10.1128/aac.06245-11","title":"The Aminopeptidase Inhibitor CHR-2863 Is an Orally Bioavailable Inhibitor of Murine Malaria","year":2012,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Malaria Research and Control","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Aminopeptidase; Malaria; Pharmacology; Biology; Bioavailability; Chemistry; Leucine; Amino acid; Biochemistry; Microbiology; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000107843,0.0002651517,0.0002489981,0.0001429459,0.0001036785,0.0001767123,0.0001900589,0.0002069064,0.001672816],"category_scores_gemma":[0.00006821498,0.00007664601,0.0001434213,0.0001103122,0.000178263,0.0001428109,0.0001042866,0.0009252147,0.0004177363],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001271538,"about_ca_system_score_gemma":0.0002630461,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003650286,"about_ca_topic_score_gemma":0.0006473338,"domain_scores_codex":[0.9999262,0.00001468959,0.000004630936,0.00001027798,0.00002691274,0.00001724506],"domain_scores_gemma":[0.9999361,0.00001046403,0.00001849932,0.000008362847,0.000006333781,0.00002026941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000504801,0.0002426637,0.0001667455,0.0000789665,0.000007411191,0.00005605408,0.00000888974,0.000265077,0.9904828,0.0001192123,0.0001782536,0.007889109],"study_design_scores_gemma":[0.0001481281,0.004511405,0.002617803,0.00001212606,0.00002654909,0.0006841681,0.00001094175,0.0007332311,0.9849438,0.00004951125,0.006255831,0.000006545537],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9798552,0.009925504,0.004339716,0.0003779522,0.00009008649,0.0001146198,0.0008129874,0.0001839511,0.004299904],"genre_scores_gemma":[0.9850888,0.005623434,0.003701165,0.00007897268,0.0000273799,0.0000436777,0.0007883979,0.00001624669,0.004631966],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001672816,"threshold_uncertainty_score":0.005596101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01880205271604954,"score_gpt":0.2754027273164445,"score_spread":0.256600674600395,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}