{"id":"W2087751655","doi":"10.1016/j.envint.2014.06.011","title":"AhR-mediated activities of polycyclic aromatic compound (PAC) mixtures are predictable by the concept of concentration addition","year":2014,"lang":"en","type":"article","venue":"Environment International","topic":"Toxic Organic Pollutants Impact","field":"Environmental Science","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Canada Research Chairs; Nanjing University; State Administration of Foreign Experts Affairs; State Key Laboratory in Marine Pollution; Knowledge Foundation; Chinese Academy of Sciences; U.S. Environmental Protection Agency","keywords":"Bioassay; Aryl hydrocarbon receptor; Environmental chemistry; Chemistry; Matrix (chemical analysis); Contamination; Polycyclic aromatic hydrocarbon; Chromatography; Biochemistry; Biology; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001733347,0.0001298041,0.0001524032,0.00001832939,0.00005950469,0.00001486869,0.0003155883,0.00005730831,0.005037597],"category_scores_gemma":[0.00009019065,0.0001014138,0.00004911932,0.00004851069,0.0005211653,0.0002442116,0.00007763066,0.00009472922,0.00006978378],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001919127,"about_ca_system_score_gemma":0.00000648063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005386505,"about_ca_topic_score_gemma":0.000005848117,"domain_scores_codex":[0.9986109,0.0001041357,0.0003111247,0.0001788253,0.0006319631,0.0001630799],"domain_scores_gemma":[0.9990872,0.0002299571,0.0004173973,0.0002124687,5.282604e-7,0.00005252139],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001191906,0.0007996999,0.04179201,0.000007935486,0.0002759475,0.000001773872,0.002580788,0.001928724,0.8840008,0.0001147515,0.04746771,0.02091064],"study_design_scores_gemma":[0.00185726,0.0003014959,0.4755836,0.00007831707,0.00006854149,0.00002174731,0.0006862021,0.01708372,0.47949,0.001263293,0.02319457,0.000371328],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905168,0.00005968737,0.003367726,0.000772312,0.0003772793,0.000233264,0.001032212,0.00002267114,0.003618027],"genre_scores_gemma":[0.9989074,0.00001873501,0.0002403284,0.0001683178,0.00007651164,0.000008232045,0.000110654,0.00001219157,0.0004575528],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4337916,"threshold_uncertainty_score":0.995872,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004945549745492436,"score_gpt":0.1943791907407171,"score_spread":0.1894336409952247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}