{"id":"W2087762900","doi":"10.1016/j.stem.2009.04.018","title":"Monoclonal Antibody-Mediated Targeting of CD123, IL-3 Receptor α Chain, Eliminates Human Acute Myeloid Leukemic Stem Cells","year":2009,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":523,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network","funders":"","keywords":"Biology; Monoclonal antibody; Stem cell; Myeloid cells; Interleukin-3 receptor; Myeloid; Cancer research; Immunology; Receptor; Antibody; Haematopoiesis; Myeloid leukemia; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001284644,0.0002097093,0.0002355527,0.0002583,0.0001889963,0.0003997975,0.0002252275,0.0002989601,0.001346537],"category_scores_gemma":[0.000137077,0.000188153,0.0001897621,0.0001557388,0.000191167,0.0001810096,0.0001960633,0.0005745545,0.0004868254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003627163,"about_ca_system_score_gemma":0.00031155,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001044922,"about_ca_topic_score_gemma":0.001484881,"domain_scores_codex":[0.9998525,0.00001681295,0.00001061501,0.00002170224,0.00005170403,0.00004661031],"domain_scores_gemma":[0.9999019,0.00003091828,0.0000207955,0.00001467064,0.00001133767,0.00002046484],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008808407,0.00003422095,0.0002827898,0.00001532401,0.000005531568,0.00006583685,0.00001655556,0.0001291943,0.9961379,0.0007034512,0.00009480181,0.002426282],"study_design_scores_gemma":[0.000028761,0.0001335676,0.001324862,0.000002092635,0.0000166213,0.0002963241,0.00001737306,0.00144123,0.9942595,0.00009094663,0.002386792,0.000001963576],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920033,0.000683318,0.004878945,0.0001201481,0.00002430345,0.00003748627,0.0001792847,0.0001318082,0.001941242],"genre_scores_gemma":[0.9948289,0.0003036478,0.001616612,0.0000287214,0.000006372762,0.00001876748,0.0003308082,0.00002718896,0.002839024],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001346537,"threshold_uncertainty_score":0.004504561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01246599178919776,"score_gpt":0.2530785261525558,"score_spread":0.240612534363358,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}