{"id":"W2087791044","doi":"10.1158/0008-5472.can-06-0494","title":"High-risk Melanoma Susceptibility Genes and Pancreatic Cancer, Neural System Tumors, and Uveal Melanoma across GenoMEL","year":2006,"lang":"en","type":"article","venue":"Cancer Research","topic":"Ocular Oncology and Treatments","field":"Medicine","cited_by":418,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Medical Research Council; National Institutes of Health; Vetenskapsrådet; Università degli Studi di Padova; Cancerfonden; Consejo Nacional de Ciencia y Tecnología; National Health and Medical Research Council; Cancer Research UK; Huntsman Cancer Foundation; University of Utah; University of Sydney; Australian Cancer Research Foundation; Huntsman Cancer Institute; Utah Department of Health; National Cancer Institute; Melanoma Research Alliance","keywords":"CDKN2A; Melanoma; Founder effect; p14arf; Cancer; Mutation; Pancreatic cancer; Genetics; Oncology; Medicine; Biology; Cancer research; Internal medicine; Gene; Allele; Haplotype; Tumor suppressor gene; Carcinogenesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007428046,0.000219805,0.0005403779,0.0001012087,0.0005314759,0.00005579945,0.00010734,0.0001677915,0.00007801337],"category_scores_gemma":[0.00003912782,0.0001731946,0.00005467492,0.0002574697,0.0005994873,0.00008546442,0.0001559763,0.0004399306,0.00001513363],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006247276,"about_ca_system_score_gemma":0.0002854681,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.04581436,"about_ca_topic_score_gemma":0.009964539,"domain_scores_codex":[0.9975731,0.0003530207,0.0002955334,0.0006296741,0.0004138517,0.0007348005],"domain_scores_gemma":[0.9988611,0.0001860637,0.00007961193,0.0003960506,0.000215421,0.0002617699],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005790544,0.0001052395,0.9783893,0.0005094277,0.0001809923,0.0004315272,0.0002668198,0.00001017109,0.004160641,0.0001338146,0.0002046124,0.01502841],"study_design_scores_gemma":[0.003806869,0.0008391649,0.9886475,0.0001632064,0.0001761943,0.0001546267,0.0006226685,0.0002120933,0.004615314,0.0001174992,0.0004738951,0.0001710172],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9672719,0.03080035,0.00000314391,0.0004465118,0.000153283,0.0008473478,0.0002400272,0.00005742499,0.0001800267],"genre_scores_gemma":[0.9961618,0.001706397,0.0001058423,0.00002568933,0.0004850638,0.0003431364,0.00004019746,0.00003403084,0.001097803],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03584982,"threshold_uncertainty_score":0.9605396,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03524421162704441,"score_gpt":0.3701015927719958,"score_spread":0.3348573811449514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}