{"id":"W2087821811","doi":"10.1038/sj.onc.1207689","title":"Histone deacetylase inhibitors activate INK4d gene through Sp1 site in its promoter","year":2004,"lang":"en","type":"article","venue":"Oncogene","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":97,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Cancer Institute; American Lebanese Syrian Associated Charities; McMaster University","keywords":"Biology; Trichostatin A; Histone deacetylase; Chromatin immunoprecipitation; Histone deacetylase 2; Molecular biology; HDAC11; Histone deacetylase inhibitor; Chromatin; Histone deacetylase 5; Cyclin-dependent kinase; Cell cycle; Histone; Cancer research; Cell biology; Promoter; Gene expression; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003192217,0.0003532741,0.0003175654,0.0001526705,0.00012486,0.00003264283,0.0003122365,0.0003754608,0.00006320241],"category_scores_gemma":[0.000142099,0.0003654618,0.0001619408,0.0004123931,0.0001519956,0.00002370516,0.0002803266,0.000348295,0.0003596687],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004303037,"about_ca_system_score_gemma":0.0004446026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002602332,"about_ca_topic_score_gemma":0.0005923102,"domain_scores_codex":[0.997481,0.0001184784,0.0004561224,0.0008106859,0.0004218988,0.0007118288],"domain_scores_gemma":[0.9988683,0.00001075108,0.0001193449,0.000657777,0.0001367432,0.0002070973],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001724923,0.0003386309,0.0001440619,0.00003100579,0.00003121821,0.0001627024,0.0003563264,0.0003507815,0.9960881,0.00002068184,0.001225759,0.001078276],"study_design_scores_gemma":[0.002122504,0.0003560164,0.0001632731,0.00005342826,0.00001004391,0.00008321825,0.00002505884,0.000008842822,0.958147,0.00004953365,0.03857454,0.0004065197],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946878,0.001646379,0.0002909412,0.0006802162,0.0002671871,0.0005335269,0.00005143513,0.00003814058,0.001804404],"genre_scores_gemma":[0.9938652,0.0002718153,0.002175099,0.0003237349,0.0006367878,0.00009641166,0.0002519673,0.00009428766,0.002284731],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03794105,"threshold_uncertainty_score":0.9998797,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01632846735696494,"score_gpt":0.3070713760925847,"score_spread":0.2907429087356198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}