{"id":"W2087821811","doi":"10.1038/sj.onc.1207689","title":"Histone deacetylase inhibitors activate INK4d gene through Sp1 site in its promoter","year":2004,"lang":"en","type":"article","venue":"Oncogene","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":97,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Cancer Institute; American Lebanese Syrian Associated Charities; McMaster University","keywords":"Biology; Trichostatin A; Histone deacetylase; Chromatin immunoprecipitation; Histone deacetylase 2; Molecular biology; HDAC11; Histone deacetylase inhibitor; Chromatin; Histone deacetylase 5; Cyclin-dependent kinase; Cell cycle; Histone; Cancer research; Cell biology; Promoter; Gene expression; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002501186,0.000509132,0.0003529796,0.0006299387,0.0003725411,0.0004454831,0.0003616621,0.0002643175,0.005078914],"category_scores_gemma":[0.0003410865,0.0003485185,0.0005606391,0.0002960025,0.0004202742,0.0003322123,0.0004274978,0.0009958972,0.001075295],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006489633,"about_ca_system_score_gemma":0.000396538,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005945145,"about_ca_topic_score_gemma":0.0008793444,"domain_scores_codex":[0.9996823,0.00004293621,0.00002332568,0.00007464088,0.00006123418,0.000115487],"domain_scores_gemma":[0.9997242,0.00007653477,0.00005808593,0.00004793765,0.00003074036,0.00006250149],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005504157,0.00008637796,0.0007213217,0.00007937078,0.00001603929,0.000105823,0.00002485105,0.0001191076,0.9938499,0.0006560046,0.0002515108,0.003539324],"study_design_scores_gemma":[0.00002844735,0.00008025203,0.001485772,0.000004526771,0.00001202456,0.00008663662,0.0000242112,0.0003102754,0.9957105,0.0001483433,0.002106354,0.000002653111],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9671578,0.006229397,0.01515134,0.0006387842,0.0004200805,0.00007624683,0.001434998,0.0005577919,0.008333494],"genre_scores_gemma":[0.9848873,0.001156267,0.003925513,0.0001112169,0.00004119402,0.00005205709,0.001291615,0.00008868901,0.008446184],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005078914,"threshold_uncertainty_score":0.01699066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01632846735696494,"score_gpt":0.3070713760925847,"score_spread":0.2907429087356198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}