{"id":"W2087900616","doi":"10.1038/nm.2544","title":"Requirement of argininosuccinate lyase for systemic nitric oxide production","year":2011,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":227,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Center for Research Resources; National Institute of General Medical Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research","keywords":"Argininosuccinate synthase; Nitric oxide; Argininosuccinate lyase; Citrulline; Arginine; Nitric oxide synthase; Extracellular; Cell biology; Phenotype; Biology; Biochemistry; Chemistry; Arginase; Endocrinology; Gene; Amino acid","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005291407,0.0002933021,0.0004787084,0.0001915779,0.0001574289,0.0005158178,0.0003439762,0.0004504985,0.001541801],"category_scores_gemma":[0.0005819449,0.0001707778,0.0002439147,0.0000868539,0.0004523383,0.0004371604,0.0002740661,0.0005176542,0.0003524739],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005103866,"about_ca_system_score_gemma":0.0005412715,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007898351,"about_ca_topic_score_gemma":0.001001012,"domain_scores_codex":[0.9996862,0.00006352307,0.00003816271,0.00006888653,0.00007983398,0.00006344775],"domain_scores_gemma":[0.9992806,0.0001985367,0.0001610035,0.000126982,0.00006199846,0.0001708312],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002837649,0.00001575727,0.0001332914,0.00001772604,0.000003302408,0.00004935974,0.000005916532,0.00002556277,0.9987293,0.000161635,0.00001744352,0.0005569579],"study_design_scores_gemma":[0.00003236672,0.0001606341,0.002765829,0.000003199514,0.000009092611,0.000477851,0.00001423003,0.001170838,0.9942271,0.00013037,0.001003208,0.000005217331],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986187,0.001957714,0.009267236,0.0004452286,0.00006499599,0.00003955964,0.0002262657,0.0001337548,0.001678232],"genre_scores_gemma":[0.991973,0.0002863097,0.005733146,0.00004596923,0.00002048325,0.00002053712,0.0002865153,0.00003128701,0.001602756],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001541801,"threshold_uncertainty_score":0.005157828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03286995246047644,"score_gpt":0.2991013126922534,"score_spread":0.266231360231777,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}