{"id":"W2087903625","doi":"10.1016/j.bmc.2007.04.017","title":"Substituted 6-amino-4H-[1,2]dithiolo[4,3-b]pyrrol-5-ones: Synthesis, structure–activity relationships, and cytotoxic activity on selected human cancer cell lines","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Synthesis of heterocyclic compounds","field":"Chemistry","cited_by":64,"is_retracted":false,"has_abstract":false,"ca_institutions":"Welichem Biotech (Canada)","funders":"National Cancer Institute; Simon Fraser University","keywords":"Chemistry; Cytotoxic T cell; Stereochemistry; Chemical synthesis; Cell culture; Cancer cell lines; Structure–activity relationship; Cytotoxicity; Cancer; Amino acid; Cancer cell; In vitro; Biochemistry; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005336929,0.0007739509,0.0007840749,0.00008739086,0.0006592575,0.00007076686,0.0005826947,0.0008842438,0.002554923],"category_scores_gemma":[0.001078364,0.0007418767,0.0001298481,0.000398557,0.0004098122,0.0002232986,0.0001458022,0.001404059,0.00001412895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008669812,"about_ca_system_score_gemma":0.000285937,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006187134,"about_ca_topic_score_gemma":0.0005844338,"domain_scores_codex":[0.9964216,0.0000802135,0.0006240035,0.001158033,0.0008260156,0.0008900939],"domain_scores_gemma":[0.9963667,0.001426801,0.0005206924,0.0009756977,0.0001901311,0.0005199384],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003185572,0.0003029603,0.01089974,0.0005531784,0.0001287932,0.00005047667,0.0001451281,0.000001078787,0.9844826,0.000002903058,0.0002719127,0.002842663],"study_design_scores_gemma":[0.0008694479,0.00002759675,0.07063743,0.000334847,0.0002274244,0.0001067082,0.0002280955,0.00004946347,0.926306,0.00002857011,0.0005051291,0.0006792541],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949871,0.0009505874,0.00004555475,0.0002608749,0.0001797968,0.000172871,0.0001198909,0.0004161055,0.002867213],"genre_scores_gemma":[0.9976892,0.0001439406,0.00008441686,0.00004355845,0.001398099,0.00003820278,0.00005234985,0.0001135733,0.0004366165],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05973769,"threshold_uncertainty_score":0.9995033,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02289875559313844,"score_gpt":0.2656843360398503,"score_spread":0.2427855804467119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}