{"id":"W2087903625","doi":"10.1016/j.bmc.2007.04.017","title":"Substituted 6-amino-4H-[1,2]dithiolo[4,3-b]pyrrol-5-ones: Synthesis, structure–activity relationships, and cytotoxic activity on selected human cancer cell lines","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Synthesis of heterocyclic compounds","field":"Chemistry","cited_by":64,"is_retracted":false,"has_abstract":false,"ca_institutions":"Welichem Biotech (Canada)","funders":"National Cancer Institute; Simon Fraser University","keywords":"Chemistry; Cytotoxic T cell; Stereochemistry; Chemical synthesis; Cell culture; Cancer cell lines; Structure–activity relationship; Cytotoxicity; Cancer; Amino acid; Cancer cell; In vitro; Biochemistry; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001144089,0.0002260599,0.0002671077,0.0001938272,0.0001532361,0.0001445589,0.0003695053,0.0002070432,0.002078791],"category_scores_gemma":[0.0001358203,0.0001571236,0.00009351082,0.0002187193,0.0001119612,0.0001895012,0.0001166119,0.0002805232,0.0006244861],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002149953,"about_ca_system_score_gemma":0.0001642069,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003565839,"about_ca_topic_score_gemma":0.001765399,"domain_scores_codex":[0.9999177,0.00001775704,0.000006549691,0.00001293786,0.00001738896,0.00002753949],"domain_scores_gemma":[0.999936,0.00001246667,0.00001796325,0.000009247608,0.000008540283,0.00001568355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006898033,0.0001445315,0.0002539133,0.000213532,0.00001110285,0.0002044831,0.00006863998,0.000568872,0.9832432,0.0006164895,0.0003170453,0.01366836],"study_design_scores_gemma":[0.0001318916,0.002041892,0.003563363,0.0000132553,0.00003338197,0.0005039457,0.00002725417,0.001052837,0.9818923,0.00009354655,0.01062807,0.00001825798],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9748102,0.008334649,0.005626224,0.000140772,0.0001152353,0.00009729172,0.0007110084,0.0001895257,0.009975198],"genre_scores_gemma":[0.9830291,0.0043772,0.005120489,0.00007238556,0.00003820225,0.00006622175,0.0007800728,0.00002479057,0.006491528],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002078791,"threshold_uncertainty_score":0.006954312,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02289875559313844,"score_gpt":0.2656843360398503,"score_spread":0.2427855804467119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}