{"id":"W2087910402","doi":"10.1074/jbc.m314314200","title":"Disruption of Pancreatic β-Cell Lipid Rafts Modifies Kv2.1 Channel Gating and Insulin Exocytosis","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Caveolin-1 and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":168,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"University of Toronto; Heart and Stroke Foundation of Canada; Banting and Best Diabetes Centre, University of Toronto; James H. Cummings Foundation","keywords":"Exocytosis; Lipid raft; Gating; Cell biology; Insulin; Chemistry; Biophysics; Biology; Endocrinology; Signal transduction; Biochemistry; Secretion","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002033385,0.0001429199,0.0002685535,0.00001728042,0.00004380452,0.00001405872,0.000137392,0.0002305999,0.00001333579],"category_scores_gemma":[0.0002164603,0.0001046183,0.0001253803,0.0000616066,0.0001363752,0.000005920788,0.0000800434,0.0001491477,6.592658e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000014454,"about_ca_system_score_gemma":0.00006243197,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003736647,"about_ca_topic_score_gemma":3.962951e-7,"domain_scores_codex":[0.9991364,0.00001949741,0.0004023541,0.0001731492,0.0001131536,0.0001553769],"domain_scores_gemma":[0.9992604,0.00002222871,0.0003706588,0.0001107577,0.0001399002,0.00009611234],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001535572,0.0001303877,0.0009843216,0.0001552461,0.00003046559,0.000007277706,0.00004553026,0.0001104566,0.9978091,0.000002688912,0.00001169883,0.0005592945],"study_design_scores_gemma":[0.0008960394,0.0003629978,0.0006638396,0.0000766984,0.00003063749,0.000157308,0.0002740755,0.00001255919,0.9968988,0.0003041663,0.0001942243,0.0001286236],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928061,0.005766307,0.0009394292,0.00007021399,0.00003628436,0.00004017361,0.00000910369,0.000003958764,0.0003283763],"genre_scores_gemma":[0.9954175,0.003637474,0.0004584312,0.00004409755,0.0003573222,0.000002437801,0.00002118603,0.000008101181,0.00005341419],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002611383,"threshold_uncertainty_score":0.4266211,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01591980195219858,"score_gpt":0.2343536177119077,"score_spread":0.2184338157597091,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}