{"id":"W2087910402","doi":"10.1074/jbc.m314314200","title":"Disruption of Pancreatic β-Cell Lipid Rafts Modifies Kv2.1 Channel Gating and Insulin Exocytosis","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Caveolin-1 and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":168,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"University of Toronto; Heart and Stroke Foundation of Canada; Banting and Best Diabetes Centre, University of Toronto; James H. Cummings Foundation","keywords":"Exocytosis; Lipid raft; Gating; Cell biology; Insulin; Chemistry; Biophysics; Biology; Endocrinology; Signal transduction; Biochemistry; Secretion","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007393798,0.0002503323,0.0001674973,0.0001180428,0.0001561831,0.00033904,0.0002049387,0.0002502311,0.001292677],"category_scores_gemma":[0.0001175,0.0001399073,0.0002284496,0.0001120895,0.0001968696,0.0002583678,0.0002580817,0.0004429186,0.000410135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002695192,"about_ca_system_score_gemma":0.0001644018,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008948257,"about_ca_topic_score_gemma":0.0008051103,"domain_scores_codex":[0.9998913,0.00001305407,0.00001121279,0.00002673668,0.0000188,0.00003884943],"domain_scores_gemma":[0.9999179,0.00001236722,0.00002855941,0.00001054092,0.000006883454,0.00002370188],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002041922,0.00003748171,0.0001104178,0.00002164128,0.00001041981,0.00004271815,0.00001717941,0.00005218621,0.9986207,0.00008884287,0.00003130021,0.0007627773],"study_design_scores_gemma":[0.00003551177,0.0001905875,0.002916178,0.000005005371,0.00002797601,0.0001695499,0.00003882654,0.0005370814,0.9936147,0.00007819472,0.002379209,0.000007177196],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970796,0.0006519427,0.001078083,0.00008377423,0.000039077,0.00001661295,0.0002060988,0.00005841288,0.0007863453],"genre_scores_gemma":[0.9968908,0.0005030829,0.0005407852,0.00007995328,0.000007233665,0.00002091367,0.0002450472,0.00002366423,0.001688493],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001292677,"threshold_uncertainty_score":0.004324436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01591980195219858,"score_gpt":0.2343536177119077,"score_spread":0.2184338157597091,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}