{"id":"W2087913623","doi":"10.1161/01.str.0000017284.77838.87","title":"Biochemical Basis of Angioedema Associated With Recombinant Tissue Plasminogen Activator Treatment","year":2002,"lang":"en","type":"article","venue":"Stroke","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Faculty of Medicine and Dentistry, University of Alberta; University of Calgary","keywords":"Bradykinin; Kinin; Angioedema; Kininogen; Plasmin; Medicine; Tissue plasminogen activator; In vitro; Hereditary angioedema; Aminopeptidase; Fibrinolysis; Pharmacology; In vivo; High-molecular-weight kininogen; Angiotensin-converting enzyme; Kallikrein; Enzyme; Biochemistry; Immunology; Internal medicine; Chemistry; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001876156,0.000201563,0.0001314601,0.0004126946,0.00009593906,0.0002333476,0.0001628272,0.0003213072,0.002062998],"category_scores_gemma":[0.0004647616,0.00004963917,0.0001700349,0.0001667763,0.0002207762,0.0001666448,0.0001288543,0.0002904216,0.0004167044],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002694534,"about_ca_system_score_gemma":0.000136061,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001578316,"about_ca_topic_score_gemma":0.00007693064,"domain_scores_codex":[0.9998602,0.00003953443,0.00001465372,0.00001451032,0.0000447438,0.0000263767],"domain_scores_gemma":[0.9997171,0.00007280125,0.0001233628,0.00001532463,0.00003641063,0.00003495295],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001506545,0.0003329914,0.02539734,0.00069856,0.00006249085,0.01850666,0.0001366966,0.0004580157,0.9200861,0.00146617,0.0006532919,0.03069518],"study_design_scores_gemma":[0.0001545089,0.002604653,0.2153926,0.0001201718,0.0001999526,0.1112061,0.0001298539,0.003623822,0.6429094,0.001923607,0.0217085,0.00002672067],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9659085,0.01794733,0.005827932,0.0004522243,0.0000964522,0.000193767,0.0002758237,0.0001488664,0.009149154],"genre_scores_gemma":[0.9970376,0.001378614,0.0007358831,0.00005275749,0.00004405355,0.00001999834,0.0001119515,0.00000423619,0.0006148741],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002062998,"threshold_uncertainty_score":0.006901443,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02661882697900347,"score_gpt":0.2528340899267842,"score_spread":0.2262152629477808,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}