{"id":"W2087950464","doi":"10.1016/s1368-7646(02)00021-3","title":"Resistance of herpesviruses to antiviral drugs: clinical impacts and molecular mechanisms","year":2002,"lang":"en","type":"review","venue":"Drug Resistance Updates","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":324,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre hospitalier universitaire de Québec; Université Laval","funders":"","keywords":"Ganciclovir; Foscarnet; Virology; Famciclovir; Herpes simplex virus; Cidofovir; Biology; Thymidine kinase; Valaciclovir; Herpesviridae; Antiviral drug; Drug resistance; Human cytomegalovirus; Nucleoside analogue; DNA polymerase; Cytomegalovirus; Virus; Polymerase; Nucleoside; Viral disease; DNA; Microbiology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005686864,0.0007086801,0.003033951,0.0003637879,0.0001238942,0.00005715514,0.0002331458,0.0003913755,0.0001043572],"category_scores_gemma":[0.000301682,0.0005623357,0.0007094367,0.0007462201,0.0002146485,0.000111403,0.0001284235,0.0004913657,0.0001806496],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001682804,"about_ca_system_score_gemma":0.0002427023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002055584,"about_ca_topic_score_gemma":0.0001275293,"domain_scores_codex":[0.9962787,0.0003212666,0.001448159,0.0009413242,0.0004671481,0.0005434242],"domain_scores_gemma":[0.9974432,0.0003479995,0.0006051353,0.001034927,0.0001656279,0.0004030817],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002185347,0.001210344,0.00007666645,0.02625335,0.001774322,0.0005229791,0.0001824802,7.502094e-8,0.000006866282,0.004475813,0.01794421,0.9473343],"study_design_scores_gemma":[0.0007001061,0.00007553306,0.00002273706,0.02219055,0.001591547,0.000008964042,0.00002712312,3.673686e-7,0.0001918948,0.0003902131,0.9743655,0.0004354216],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006301739,0.989424,0.00008802327,0.0002051074,0.0002251621,0.00138802,0.0002936181,0.0001004314,0.007645418],"genre_scores_gemma":[0.001960911,0.9870592,0.005334311,0.0002797933,0.00009410037,0.0001187132,0.000087471,0.0001335664,0.0049319],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9564213,"threshold_uncertainty_score":0.9996828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03304748137064542,"score_gpt":0.3666449093710895,"score_spread":0.3335974280004441,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}