{"id":"W2087950464","doi":"10.1016/s1368-7646(02)00021-3","title":"Resistance of herpesviruses to antiviral drugs: clinical impacts and molecular mechanisms","year":2002,"lang":"en","type":"review","venue":"Drug Resistance Updates","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":324,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre hospitalier universitaire de Québec; Université Laval","funders":"","keywords":"Ganciclovir; Foscarnet; Virology; Famciclovir; Herpes simplex virus; Cidofovir; Biology; Thymidine kinase; Valaciclovir; Herpesviridae; Antiviral drug; Drug resistance; Human cytomegalovirus; Nucleoside analogue; DNA polymerase; Cytomegalovirus; Virus; Polymerase; Nucleoside; Viral disease; DNA; Microbiology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008695749,0.000785728,0.001749247,0.001643211,0.000232737,0.001142993,0.000887098,0.001199415,0.00289546],"category_scores_gemma":[0.0009659358,0.0002411857,0.0004332258,0.001735166,0.0003882071,0.001395436,0.0003653122,0.001348636,0.001383122],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004828362,"about_ca_system_score_gemma":0.0007475402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007768773,"about_ca_topic_score_gemma":0.001482058,"domain_scores_codex":[0.9997725,0.00004432306,0.00003894051,0.00003601622,0.00008899141,0.00001921939],"domain_scores_gemma":[0.9994022,0.0003435959,0.0000717874,0.00001587232,0.0001350576,0.00003148166],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00014084,0.0000694337,0.0002561758,0.005707258,0.0000523276,0.0003130824,0.00004240634,0.0001783521,0.00240942,0.001095482,0.01425378,0.9754815],"study_design_scores_gemma":[0.0000620635,0.0002596836,0.001660438,0.001876784,0.0002339629,0.003981634,0.00009197231,0.0001443661,0.001708395,0.001160086,0.988799,0.00002152665],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002478167,0.9981107,0.0002023726,0.000269169,0.0002255211,0.000004752069,0.00001126971,0.000008336451,0.0009201687],"genre_scores_gemma":[0.001029621,0.9971456,0.0003758032,0.0002603705,0.0003544498,0.000006725986,0.00002658242,0.000001359037,0.0007993703],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00289546,"threshold_uncertainty_score":0.009686351,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03304748137064542,"score_gpt":0.3666449093710895,"score_spread":0.3335974280004441,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}