{"id":"W2087962053","doi":"10.1172/jci29528","title":"Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2","year":2007,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":332,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; McGill University","keywords":"Insulin resistance; Endocrinology; Internal medicine; Adipose tissue; PI3K/AKT/mTOR pathway; P70-S6 Kinase 1; Ribosomal protein s6; Lipolysis; Biology; Protein kinase B; Adipogenesis; Insulin; Signal transduction; Medicine; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002241685,0.001202279,0.0006327755,0.00155053,0.0002892819,0.0005863791,0.0003308702,0.000644764,0.002556317],"category_scores_gemma":[0.0001797111,0.0006262099,0.0004591077,0.0006210523,0.0006355963,0.0004296367,0.0003526136,0.001647214,0.0006883952],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004734944,"about_ca_system_score_gemma":0.0002726876,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006652147,"about_ca_topic_score_gemma":0.0009414994,"domain_scores_codex":[0.9996265,0.00005067952,0.00004092919,0.0001154324,0.0000926005,0.00007389222],"domain_scores_gemma":[0.9996542,0.00002581928,0.0001203446,0.00003289753,0.00002342639,0.0001433195],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008090658,0.00009390399,0.0004183417,0.00003123061,0.00001917336,0.00009110718,0.00001927988,0.00005862379,0.9970856,0.0001084458,0.00006633253,0.001198877],"study_design_scores_gemma":[0.0004052979,0.002409667,0.04746429,0.00004651003,0.0001947651,0.002471869,0.0001201537,0.002571634,0.938379,0.0004595698,0.005418062,0.0000592803],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913744,0.001554416,0.003379917,0.0002920251,0.00006811984,0.00004392891,0.001464831,0.0003588792,0.001463505],"genre_scores_gemma":[0.9811231,0.002086695,0.006194555,0.0002393899,0.00004592107,0.0002045616,0.002272339,0.0002353677,0.007598034],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002556317,"threshold_uncertainty_score":0.008551776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05349405494463537,"score_gpt":0.3604036181771676,"score_spread":0.3069095632325322,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}