{"id":"W2087962373","doi":"10.1210/endo.142.6.8080","title":"X-Linked Inhibitor of Apoptosis Protein Activates the Phosphatidylinositol 3-Kinase/Akt Pathway in Rat Granulosa Cells during Follicular Development<sup>1</sup>","year":2001,"lang":"en","type":"article","venue":"Endocrinology","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"","keywords":"XIAP; Protein kinase B; Follicular atresia; Inhibitor of apoptosis; Granulosa cell; Apoptosis; Internal medicine; Endocrinology; Biology; PI3K/AKT/mTOR pathway; Follicular phase; Signal transduction; Chemistry; Ovarian follicle; Cell biology; Programmed cell death; Medicine; Biochemistry; Caspase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001049764,0.0002376571,0.0002560021,0.0001008291,0.0001410774,0.00001405712,0.0002383063,0.0001980322,0.00003816499],"category_scores_gemma":[0.0000297148,0.0001851525,0.0001076044,0.0001813683,0.00009548608,0.000008768244,0.0001647758,0.0001591509,0.000009985771],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003098373,"about_ca_system_score_gemma":0.00007152768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003605995,"about_ca_topic_score_gemma":0.00002217703,"domain_scores_codex":[0.9984272,0.0001220453,0.0004159045,0.0004180134,0.0001487271,0.0004681384],"domain_scores_gemma":[0.9993442,0.00001886789,0.0001503551,0.0003693203,0.00006430932,0.00005293558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001575327,0.000123934,0.0009811147,0.00004183012,0.00004539219,0.00001976384,0.0002421898,0.0004942927,0.9930532,0.0001856991,0.00002891609,0.004626125],"study_design_scores_gemma":[0.00117795,0.0001075339,0.0009137814,0.00003846616,0.000008606968,0.00002399209,0.0002085806,0.00005648176,0.9828732,0.00007318561,0.0143076,0.0002106144],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978817,0.0007796948,0.0002597322,0.0001511975,0.0001465636,0.0006300352,0.000004052744,0.00001938831,0.0001276087],"genre_scores_gemma":[0.9974784,0.0002672039,0.000966099,0.00004030673,0.0001506483,0.0001429458,0.00006350979,0.00002839269,0.0008625506],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01427868,"threshold_uncertainty_score":0.75503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007405793559753863,"score_gpt":0.2082349319562391,"score_spread":0.2008291383964853,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}