{"id":"W2087962373","doi":"10.1210/endo.142.6.8080","title":"X-Linked Inhibitor of Apoptosis Protein Activates the Phosphatidylinositol 3-Kinase/Akt Pathway in Rat Granulosa Cells during Follicular Development<sup>1</sup>","year":2001,"lang":"en","type":"article","venue":"Endocrinology","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"","keywords":"XIAP; Protein kinase B; Follicular atresia; Inhibitor of apoptosis; Granulosa cell; Apoptosis; Internal medicine; Endocrinology; Biology; PI3K/AKT/mTOR pathway; Follicular phase; Signal transduction; Chemistry; Ovarian follicle; Cell biology; Programmed cell death; Medicine; Biochemistry; Caspase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001446905,0.0002732526,0.0001946536,0.0002234247,0.0001410588,0.0002460395,0.0001295009,0.0001513844,0.0006634886],"category_scores_gemma":[0.00008771043,0.0001605823,0.0002566658,0.0001638733,0.0002166523,0.0001928234,0.0001458414,0.0003989316,0.0003720127],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002519116,"about_ca_system_score_gemma":0.0002474449,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006107602,"about_ca_topic_score_gemma":0.0007214459,"domain_scores_codex":[0.9999161,0.00001328045,0.00001136583,0.00001324207,0.00002225166,0.00002378612],"domain_scores_gemma":[0.9999195,0.00001017769,0.00003079033,0.00001531611,0.000008793691,0.00001543824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004267274,0.00002371482,0.0006358924,0.00004533391,0.000005138683,0.0001016201,0.00002286155,0.00003475179,0.9971147,0.00007585885,0.00002644939,0.001486973],"study_design_scores_gemma":[0.00006692879,0.0004754982,0.01904249,0.00001023285,0.00003114209,0.0006636883,0.00007055801,0.0005302844,0.9765939,0.00009389445,0.002417204,0.000004295119],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934173,0.003155852,0.001768357,0.00009444384,0.00001936993,0.00003476198,0.0003675244,0.0000471054,0.001095364],"genre_scores_gemma":[0.9922187,0.001869683,0.002644053,0.00006847486,0.00001566197,0.00008498047,0.0009607291,0.00001227949,0.002125504],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006634886,"threshold_uncertainty_score":0.002219617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007405793559753863,"score_gpt":0.2082349319562391,"score_spread":0.2008291383964853,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}