{"id":"W2087995224","doi":"10.3389/fgene.2013.00149","title":"Structural disorder and the loss of RNA homeostasis in aging and neurodegenerative disease","year":2013,"lang":"en","type":"article","venue":"Frontiers in Genetics","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"RNA; Biology; Disease; RNA-binding protein; Ribonucleoprotein; Mechanism (biology); Homeostasis; Protein aggregation; Cell biology; Computational biology; Genetics; Medicine; Gene; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009378688,0.00008360794,0.000117609,0.00004972339,0.00003452927,0.00002247667,0.00009381076,0.0000351421,0.00000214271],"category_scores_gemma":[0.00006046884,0.00006061343,0.0000190918,0.00007129344,0.0002873076,0.000003966465,0.0001164271,0.00007501569,1.04725e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004794328,"about_ca_system_score_gemma":0.00002292726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001207911,"about_ca_topic_score_gemma":0.00007060304,"domain_scores_codex":[0.9993535,0.0000885384,0.0001323116,0.0001766135,0.00007872821,0.0001702517],"domain_scores_gemma":[0.9997123,0.00001121679,0.00003082642,0.0001524939,0.00002797839,0.00006511631],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000136016,0.00001146472,0.9512889,0.00003470719,0.00002039229,0.000004514432,0.0002244894,0.0006875634,0.01719454,0.0000396063,0.0003295741,0.03002819],"study_design_scores_gemma":[0.002687846,0.00008505579,0.9514943,0.0000209979,0.00001146165,0.00000251188,0.0007008972,0.03294029,0.01054125,0.00113114,0.0001951687,0.0001890583],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830641,0.01572084,0.0005452909,0.0003486014,0.00005407893,0.000239195,0.000007987702,9.799683e-7,0.00001893852],"genre_scores_gemma":[0.9943811,0.004157744,0.001247338,0.00006656133,0.00002487626,0.00001723416,0.000007796779,0.000008556146,0.00008873483],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03225273,"threshold_uncertainty_score":0.2471744,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005143275672521984,"score_gpt":0.2292683671862761,"score_spread":0.2241250915137541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}