{"id":"W2088020647","doi":"10.2174/1568011043482133","title":"Drug Binding Domains of MRP1 (ABCC1) as Revealed by Photoaffinity Labeling","year":2004,"lang":"en","type":"review","venue":"Current Medicinal Chemistry - Anti-Cancer Agents","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"ABCC1; Efflux; Drug; Photoaffinity labeling; Drug resistance; Multiple drug resistance; Binding site; ATP-binding cassette transporter; Plasma protein binding; Biochemistry; Biology; Pharmacology; Chemistry; Transporter; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002553848,0.0003481615,0.0002941593,0.0002935205,0.0003771486,0.0004296098,0.0005790747,0.0007489905,0.002810934],"category_scores_gemma":[0.0002553914,0.0003533359,0.0003241539,0.0002680455,0.0002472586,0.000350404,0.0003517029,0.0009267181,0.00131357],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007632643,"about_ca_system_score_gemma":0.0002821435,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001740362,"about_ca_topic_score_gemma":0.002755779,"domain_scores_codex":[0.9997731,0.00005023886,0.000006933851,0.00005196894,0.00004638365,0.00007148449],"domain_scores_gemma":[0.9998916,0.00003701317,0.0000173379,0.00001770686,0.00002226666,0.0000140533],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005512505,0.00001397594,0.00007238412,0.00004429765,0.000004429678,0.00004789471,0.00001797791,0.0001077882,0.9971166,0.0004680984,0.0002082913,0.001843112],"study_design_scores_gemma":[0.00001626312,0.0001731198,0.001170309,0.000009795473,0.00001810867,0.0002979808,0.00002629138,0.002372088,0.9855177,0.0001605903,0.0102246,0.00001313528],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.8909836,0.01061933,0.06732345,0.001501485,0.0002063416,0.0002264154,0.0006999898,0.0007768217,0.02766262],"genre_scores_gemma":[0.9458584,0.00450111,0.03387288,0.0006443562,0.00004219611,0.0001826506,0.0009528762,0.0001241757,0.01382139],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.002810934,"threshold_uncertainty_score":0.009403467,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05095827744293301,"score_gpt":0.3800256260312525,"score_spread":0.3290673485883195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}