{"id":"W2088027239","doi":"10.1038/labinvest.3700325","title":"Increased angiopoietin2 expression is associated with endothelial apoptosis and blood–brain barrier breakdown","year":2005,"lang":"en","type":"article","venue":"Laboratory Investigation","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":81,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; St. Michael's Hospital; University Health Network","funders":"","keywords":"Blood–brain barrier; Apoptosis; Endothelium; TUNEL assay; Endothelial stem cell; Horseradish peroxidase; Biology; Angiopoietin; Angiopoietin receptor; Vascular permeability; Endocrinology; Pathology; Internal medicine; Central nervous system; Vascular endothelial growth factor; Angiogenesis; Medicine; Biochemistry; In vitro; Cancer research; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000161073,0.0001889012,0.0002527604,0.0007004908,0.000245191,0.000336043,0.0001896816,0.000267943,0.001484751],"category_scores_gemma":[0.0002171364,0.0001452038,0.0001816414,0.0004535905,0.0002659335,0.0002233806,0.0001627344,0.000627027,0.0002257106],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003235833,"about_ca_system_score_gemma":0.0001378812,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004682935,"about_ca_topic_score_gemma":0.0004047574,"domain_scores_codex":[0.9998775,0.0000253241,0.000008918576,0.00002485869,0.0000300027,0.00003332595],"domain_scores_gemma":[0.9997769,0.00004178781,0.00007271845,0.0000231939,0.00002865988,0.00005681733],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009408282,0.00009957299,0.002549623,0.00005344325,0.0000236069,0.0008567584,0.00003141551,0.00003035794,0.9929233,0.0001911988,0.000160062,0.002139963],"study_design_scores_gemma":[0.0001142227,0.0006600039,0.1316111,0.000009108739,0.0000734917,0.008846774,0.0001303168,0.001109359,0.8529353,0.0003396158,0.004157855,0.00001290092],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937769,0.002234613,0.00249003,0.00009591004,0.00003173604,0.00001826123,0.0002023385,0.00005692213,0.001093243],"genre_scores_gemma":[0.9956098,0.0007550785,0.001152463,0.00004446014,0.00004667485,0.00004362457,0.0004057975,0.00000875928,0.001933368],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001484751,"threshold_uncertainty_score":0.004966974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006216888095753951,"score_gpt":0.213404532631705,"score_spread":0.207187644535951,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}