{"id":"W2088027239","doi":"10.1038/labinvest.3700325","title":"Increased angiopoietin2 expression is associated with endothelial apoptosis and blood–brain barrier breakdown","year":2005,"lang":"en","type":"article","venue":"Laboratory Investigation","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":81,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; St. Michael's Hospital; University Health Network","funders":"","keywords":"Blood–brain barrier; Apoptosis; Endothelium; TUNEL assay; Endothelial stem cell; Horseradish peroxidase; Biology; Angiopoietin; Angiopoietin receptor; Vascular permeability; Endocrinology; Pathology; Internal medicine; Central nervous system; Vascular endothelial growth factor; Angiogenesis; Medicine; Biochemistry; In vitro; Cancer research; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000187882,0.0001645191,0.0001234976,0.00003567704,0.0001268442,0.00003465104,0.00007705596,0.0001846428,0.00005920388],"category_scores_gemma":[0.00011198,0.0001425065,0.00003530288,0.0001412282,0.0001456666,0.00001641185,0.00003506481,0.00005793633,0.000004783204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000171879,"about_ca_system_score_gemma":0.0001327221,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002027329,"about_ca_topic_score_gemma":0.00002862239,"domain_scores_codex":[0.9990715,0.0001048365,0.0001599006,0.000328602,0.0001561887,0.0001789086],"domain_scores_gemma":[0.9993548,0.00001946183,0.0001187504,0.0002073092,0.0001483066,0.0001513998],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003740676,0.00002475037,0.02050549,0.000006609977,0.00005187776,5.328217e-7,0.0001431568,0.00000825679,0.9703212,0.00002359853,0.008639903,0.0002371801],"study_design_scores_gemma":[0.0008387704,0.0001360282,0.005066244,0.00004341744,0.00004728736,0.000001995577,0.00004183207,0.00003310971,0.9748815,0.00002013394,0.0186813,0.0002083597],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982066,0.0005725186,0.00006635621,0.0005788472,0.00003296315,0.0001324993,0.0002249513,0.00002696805,0.0001583349],"genre_scores_gemma":[0.9936855,0.00005720462,0.0009683757,0.004364337,0.0003457697,0.00004305783,0.0002197805,0.00003025161,0.0002857647],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01543925,"threshold_uncertainty_score":0.5811245,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006216888095753951,"score_gpt":0.213404532631705,"score_spread":0.207187644535951,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}