{"id":"W2088114948","doi":"10.1016/j.toxlet.2008.09.007","title":"MG-132 inhibits the TCDD-mediated induction of Cyp1a1 at the catalytic activity but not the mRNA or protein levels in Hepa 1c1c7 cells","year":2008,"lang":"en","type":"article","venue":"Toxicology Letters","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Aryl hydrocarbon receptor; Heme; Cytochrome P450; Messenger RNA; Heme oxygenase; Chemistry; CYP1A2; Enzyme inducer; Cytochrome; Enzyme; Oxygenase; Biochemistry; Gene expression; Molecular biology; Gene; Biology; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004435311,0.0002081018,0.0002468113,0.00004920548,0.0002391926,0.000008779266,0.0003755424,0.0002351476,0.00004191303],"category_scores_gemma":[0.0001534689,0.0001109248,0.0001098997,0.0002162183,0.0007954292,0.00000906953,0.0002025172,0.0003529565,0.00002104583],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000621779,"about_ca_system_score_gemma":0.0001831879,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003032764,"about_ca_topic_score_gemma":0.001351013,"domain_scores_codex":[0.9984703,0.0003390443,0.0002732115,0.0003568841,0.000182272,0.0003783041],"domain_scores_gemma":[0.9990266,0.0000994681,0.000212043,0.0005725355,0.00004278268,0.00004658151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003111578,0.00006819529,0.0001509225,0.00001005878,0.00005044221,0.000005529231,0.0003818574,0.00007757923,0.9921029,0.000004143716,0.005771982,0.001065284],"study_design_scores_gemma":[0.0008223495,0.0001122441,0.01974002,0.000006924931,0.00002756814,0.0000824981,0.00007004417,0.00001492828,0.953787,0.000003534014,0.02518777,0.0001451124],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871653,0.000295051,0.00003380398,0.01083491,0.0007150371,0.0008162411,0.00005496438,0.000009943779,0.00007472419],"genre_scores_gemma":[0.9926803,0.0001602761,0.00001741468,0.005032303,0.0006143443,0.0001511162,0.00002055639,0.00002256963,0.001301191],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03831585,"threshold_uncertainty_score":0.4523384,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02519947336395449,"score_gpt":0.2433095914840278,"score_spread":0.2181101181200732,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}