{"id":"W2088123597","doi":"10.1182/blood-2004-10-3913","title":"CHIR-258, a novel, multitargeted tyrosine kinase inhibitor for the potential treatment of t(4;14) multiple myeloma","year":2004,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":289,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Cancer research; MAPK/ERK pathway; Fibroblast growth factor receptor 3; Tyrosine kinase; Receptor tyrosine kinase; Tyrosine-kinase inhibitor; Biology; Cytotoxic T cell; Kinase; Molecular biology; Fibroblast growth factor; Cell biology; Signal transduction; Receptor; In vitro; Cancer; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001018639,0.0002705146,0.0004091068,0.0001165211,0.0001916062,0.00002007476,0.0001178764,0.0001160152,0.00004133797],"category_scores_gemma":[0.0003047392,0.0001635062,0.0003240846,0.0001984629,0.0001309848,0.00006077689,0.00003914909,0.00009144216,0.00002471817],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001173332,"about_ca_system_score_gemma":0.0002175216,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005312993,"about_ca_topic_score_gemma":0.0001830334,"domain_scores_codex":[0.9983544,0.00001661868,0.0003608337,0.0003645993,0.0004183638,0.0004851543],"domain_scores_gemma":[0.9987045,0.0002060614,0.0001064048,0.0005022745,0.0002376647,0.000243126],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005592811,0.03156974,0.0250752,0.0003029239,0.002966481,0.000405515,0.0007575637,0.0002177865,0.9111145,0.0002066795,0.000156616,0.02163417],"study_design_scores_gemma":[0.1169818,0.005526473,0.1438147,0.0001495845,0.001060264,0.0001295267,0.0001576167,0.001088751,0.7284619,0.00005597202,0.002331493,0.0002418144],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923294,0.002007234,0.00136423,0.0008697158,0.0001826566,0.002649689,0.0004525499,0.00006994828,0.00007462578],"genre_scores_gemma":[0.9870285,0.0001810169,0.01116888,0.00004556882,0.0004083679,0.0004116791,0.0002308704,0.00004638024,0.0004787425],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1826526,"threshold_uncertainty_score":0.6667589,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02464544621906841,"score_gpt":0.2835323477386202,"score_spread":0.2588869015195518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}