{"id":"W2088123597","doi":"10.1182/blood-2004-10-3913","title":"CHIR-258, a novel, multitargeted tyrosine kinase inhibitor for the potential treatment of t(4;14) multiple myeloma","year":2004,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":289,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Cancer research; MAPK/ERK pathway; Fibroblast growth factor receptor 3; Tyrosine kinase; Receptor tyrosine kinase; Tyrosine-kinase inhibitor; Biology; Cytotoxic T cell; Kinase; Molecular biology; Fibroblast growth factor; Cell biology; Signal transduction; Receptor; In vitro; Cancer; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007684932,0.0003557352,0.0002500103,0.0003083598,0.0001439489,0.000183112,0.0002403909,0.0002656236,0.0009154441],"category_scores_gemma":[0.00005502124,0.000104136,0.0002015081,0.0001626767,0.0001465696,0.0001312429,0.0001500554,0.0005674558,0.000318859],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000276135,"about_ca_system_score_gemma":0.0002046195,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003552515,"about_ca_topic_score_gemma":0.001153064,"domain_scores_codex":[0.9999658,0.000004892841,0.000002637643,0.0000064474,0.00001110547,0.000009142809],"domain_scores_gemma":[0.999981,0.000002920991,0.000005841245,0.000001293488,0.000002443165,0.000006465342],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007968214,0.000554366,0.0005976246,0.0003019252,0.00003084751,0.0007585944,0.00003761483,0.0009842322,0.9243807,0.0003601222,0.001672662,0.06952446],"study_design_scores_gemma":[0.001642669,0.01572729,0.01202556,0.00008170266,0.0001863239,0.006726738,0.00004726711,0.004211012,0.9152884,0.0001819914,0.04382362,0.00005741247],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.960075,0.02194267,0.005101224,0.0005593664,0.0001951594,0.000371094,0.0006432333,0.0003272423,0.01078502],"genre_scores_gemma":[0.9727517,0.0137237,0.005570062,0.0002844298,0.0000871322,0.000207453,0.001260922,0.00001600825,0.006098628],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009154441,"threshold_uncertainty_score":0.003062427,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02464544621906841,"score_gpt":0.2835323477386202,"score_spread":0.2588869015195518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}