{"id":"W2088155080","doi":"10.1074/jbc.m007215200","title":"A Polymorphic Protease-activated Receptor 2 (PAR2) Displaying Reduced Sensitivity to Trypsin and Differential Responses to PAR Agonists","year":2000,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Blood Coagulation and Thrombosis Mechanisms","field":"Medicine","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Medical Research Council; Fondation pour la Recherche Médicale; Amgen","keywords":"Protease-activated receptor 2; Trypsin; Protease; Sensitivity (control systems); Protease-activated receptor; Receptor; Chemistry; Differential (mechanical device); Enzyme; Biochemistry; Internal medicine; Medicine; Enzyme-linked receptor; Physics; Thrombin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001451453,0.0002987447,0.0003253226,0.0001299301,0.0001235364,0.0003203924,0.0002153728,0.0002834263,0.001791903],"category_scores_gemma":[0.0001665228,0.0001220202,0.000301307,0.0001757935,0.0001955587,0.0001685057,0.0001969766,0.0005665046,0.0004536248],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001675094,"about_ca_system_score_gemma":0.00007479528,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004121069,"about_ca_topic_score_gemma":0.0004604191,"domain_scores_codex":[0.9997743,0.00003298622,0.00002079272,0.00006345092,0.00006008346,0.00004851042],"domain_scores_gemma":[0.9999187,0.00001525947,0.00002426144,0.00001348309,0.000006666323,0.00002157715],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008647925,0.00001171666,0.0001627152,0.000006647007,0.000003832612,0.00005954059,0.000003953044,0.00001846164,0.999146,0.0000213789,0.00002747973,0.0004518319],"study_design_scores_gemma":[0.00005677007,0.0009461706,0.01981281,0.000003951439,0.00003909576,0.005446679,0.00004719254,0.001215386,0.9682073,0.00006411015,0.004145688,0.00001475154],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964987,0.0004569731,0.001676224,0.00008439142,0.00001893692,0.00001420093,0.0005746527,0.0000392011,0.0006367601],"genre_scores_gemma":[0.9931949,0.0004569833,0.002799335,0.0001151167,0.00001871772,0.00004557605,0.00132364,0.00002240496,0.002023311],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001791903,"threshold_uncertainty_score":0.005994499,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03808854632418588,"score_gpt":0.286183786671081,"score_spread":0.2480952403468951,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}