{"id":"W2088208507","doi":"10.1007/s00213-012-2922-7","title":"Clozapine and therapeutic drug monitoring: is there sufficient evidence for an upper threshold?","year":2012,"lang":"en","type":"review","venue":"Psychopharmacology","topic":"Schizophrenia research and treatment","field":"Medicine","cited_by":97,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"","keywords":"Clozapine; Ceiling effect; Medicine; Seizure threshold; Drug; Randomized controlled trial; Clinical trial; Pharmacokinetics; Pharmacology; Internal medicine; Epilepsy; Psychiatry; Schizophrenia (object-oriented programming); Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003833576,0.001271392,0.007234099,0.00171886,0.0003627249,0.002570762,0.002428767,0.003595071,0.005731703],"category_scores_gemma":[0.006256511,0.0005066644,0.001643363,0.001607634,0.001348774,0.002940005,0.001098807,0.004834477,0.001542],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001523062,"about_ca_system_score_gemma":0.003162243,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002638898,"about_ca_topic_score_gemma":0.007162053,"domain_scores_codex":[0.998431,0.0004349872,0.0003331348,0.0001945177,0.0005112787,0.0000949656],"domain_scores_gemma":[0.9943585,0.004178549,0.0006794487,0.0001079255,0.0005148418,0.0001608028],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.001136199,0.00008997798,0.0004940009,0.04174806,0.0009218271,0.000271288,0.00006285658,0.000196776,0.001032995,0.005066538,0.01772179,0.9312577],"study_design_scores_gemma":[0.001093817,0.0006715278,0.006268458,0.06943105,0.004622488,0.002824758,0.0003018675,0.0004754516,0.001376117,0.01725714,0.895532,0.0001453356],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000158443,0.9974084,0.0001331223,0.001275154,0.0001888457,0.0000064802,0.00002218052,0.000006577793,0.0008006165],"genre_scores_gemma":[0.004115055,0.9923859,0.0006410416,0.002080662,0.0003596575,0.00001743977,0.00006277716,0.000003789737,0.0003337183],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.007234099,"threshold_uncertainty_score":0.02027416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.253797630079828,"score_gpt":0.5051845305104522,"score_spread":0.2513869004306242,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}