{"id":"W2088234095","doi":"10.1016/j.molimm.2008.08.003","title":"Mutational analyses reveal that the staphylococcal immune evasion molecule Sbi and complement receptor 2 share overlapping contact residues on C3d: Implications for the controversy regarding the CR2/C3d co-crystal structure","year":2008,"lang":"en","type":"article","venue":"Molecular Immunology","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Evasion (ethics); Complement (music); Immune system; Complement receptor; Microbiology; Molecule; Chemistry; Biology; Immunology; Computational biology; Complement system; Genetics; Gene; Organic chemistry; Mutant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002532178,0.0002503832,0.0003906392,0.000119275,0.001219145,0.00006040638,0.0002354347,0.0001115095,0.000191835],"category_scores_gemma":[0.0003057742,0.0001360778,0.0003194801,0.0002170063,0.0003724131,0.00005995988,0.00008723998,0.0003742324,0.000004677643],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001184425,"about_ca_system_score_gemma":0.0001068481,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001059526,"about_ca_topic_score_gemma":0.00002698813,"domain_scores_codex":[0.99833,0.0002755878,0.0003914516,0.0003750722,0.0002906893,0.0003372116],"domain_scores_gemma":[0.9981449,0.0007020009,0.0002547271,0.0006004855,0.0002447396,0.00005316135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005171561,0.00005715422,0.0009227744,0.00001710764,0.001078022,0.00001564215,0.0004076044,0.0001050801,0.9893333,0.003570657,0.003428857,0.0005466116],"study_design_scores_gemma":[0.01542388,0.001938364,0.5433508,0.0007280015,0.001803187,0.001156981,0.009203554,0.002559846,0.3855524,0.002119059,0.03515225,0.001011668],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9558612,0.003220554,0.008668532,0.02953172,0.00006014886,0.00151959,0.0007505953,0.00005374728,0.000333931],"genre_scores_gemma":[0.9955698,0.0001305252,0.0002081409,0.002826479,0.00008046972,0.0001576446,0.0008769757,0.00002651677,0.0001234446],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6037809,"threshold_uncertainty_score":0.9376798,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04840419424571932,"score_gpt":0.3360103170686699,"score_spread":0.2876061228229505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}