{"id":"W2088244871","doi":"10.1016/j.freeradbiomed.2005.07.012","title":"The role of oxidative stress in the modulation of aryl hydrocarbon receptor-regulated genes by As3+, Cd2+, and Cr6+","year":2005,"lang":"en","type":"article","venue":"Free Radical Biology and Medicine","topic":"Toxic Organic Pollutants Impact","field":"Environmental Science","cited_by":86,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Aryl hydrocarbon receptor; Chemistry; Oxidative stress; Glutathione; Heme oxygenase; Messenger RNA; Gene expression; Enzyme inducer; Enzyme; Buthionine sulfoximine; Biochemistry; Oxidative phosphorylation; Metallothionein; Antioxidant; Molecular biology; Heme; Gene; Transcription factor; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003220761,0.0003553531,0.0004024636,0.0002605285,0.000343959,0.0006389344,0.0003691375,0.0005965073,0.001872627],"category_scores_gemma":[0.0002380904,0.0001689098,0.0003383749,0.0002321636,0.0004408279,0.000369534,0.0002441299,0.0004075556,0.0003932176],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004021903,"about_ca_system_score_gemma":0.0002967794,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001159142,"about_ca_topic_score_gemma":0.001373168,"domain_scores_codex":[0.9997535,0.00006800634,0.00002166006,0.0000424898,0.00003758608,0.00007671137],"domain_scores_gemma":[0.999719,0.00005353702,0.00005261259,0.00002822796,0.00006621263,0.00008046444],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002030409,0.00005814018,0.000675683,0.00006484398,0.00001220638,0.00005469917,0.00004093525,0.0000778285,0.9946562,0.0002511774,0.00006179052,0.002016006],"study_design_scores_gemma":[0.0001804056,0.0008561295,0.01674688,0.00001124083,0.00006199108,0.0003249293,0.0001758875,0.001631155,0.9765672,0.0006647905,0.002759706,0.00001970502],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944813,0.00168501,0.002022215,0.0004187589,0.00007737835,0.00001808287,0.0001977581,0.00007093327,0.001028604],"genre_scores_gemma":[0.9946737,0.0006758454,0.00127594,0.000154194,0.000032718,0.00002189944,0.0002276042,0.00002127641,0.002916843],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001872627,"threshold_uncertainty_score":0.006264567,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005004260915277507,"score_gpt":0.2322924188477125,"score_spread":0.227288157932435,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}