{"id":"W2088257765","doi":"10.1242/dev.025916","title":"Numb mediates the interaction between Wnt and Notch to modulate primitive erythropoietic specification from the hemangioblast","year":2008,"lang":"en","type":"article","venue":"Development","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute","keywords":"Biology; Wnt signaling pathway; Notch signaling pathway; Hemangioblast; Cell biology; NUMB; Embryonic stem cell; Somite; Cell fate determination; Notch proteins; Erythropoiesis; Haematopoiesis; Signal transduction; Stem cell; Embryogenesis; Genetics; Transcription factor; Embryo; Gene; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001463917,0.0001010875,0.00007394908,0.00001514812,0.0002208887,0.00002283678,0.0001074136,0.00005346929,0.00001053912],"category_scores_gemma":[0.00004779945,0.00006481085,0.00002283465,0.00005925081,0.000053151,0.000003286076,0.00009521566,0.00005881942,0.00002879573],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002401252,"about_ca_system_score_gemma":0.00004043978,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003493972,"about_ca_topic_score_gemma":0.00005013362,"domain_scores_codex":[0.9993001,0.00004640187,0.0001770138,0.0002296956,0.0001297589,0.0001170243],"domain_scores_gemma":[0.9995961,0.000053558,0.00006208634,0.0001776887,0.00006379431,0.00004678723],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001063369,0.00009628916,0.1311078,0.00001073393,0.0003026887,0.000003083003,0.01722222,0.0003721371,0.7452433,0.00008753609,0.002148354,0.1032995],"study_design_scores_gemma":[0.00009894904,0.00003027357,0.5233977,0.000008096192,0.000007598425,0.000001034615,0.0002304862,0.00001802042,0.4445077,0.00006814904,0.03154396,0.00008803306],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919685,0.0004036534,0.005655736,0.001432236,0.000116107,0.000232072,0.000006809517,0.000006280746,0.0001786638],"genre_scores_gemma":[0.9971524,0.0003877156,0.001718375,0.000157636,0.0002631205,0.00002422007,0.0001678774,0.00001134191,0.000117316],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3922898,"threshold_uncertainty_score":0.264291,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02859379185949744,"score_gpt":0.2580592481677103,"score_spread":0.2294654563082129,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}