{"id":"W2088257765","doi":"10.1242/dev.025916","title":"Numb mediates the interaction between Wnt and Notch to modulate primitive erythropoietic specification from the hemangioblast","year":2008,"lang":"en","type":"article","venue":"Development","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute","keywords":"Biology; Wnt signaling pathway; Notch signaling pathway; Hemangioblast; Cell biology; NUMB; Embryonic stem cell; Somite; Cell fate determination; Notch proteins; Erythropoiesis; Haematopoiesis; Signal transduction; Stem cell; Embryogenesis; Genetics; Transcription factor; Embryo; Gene; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001614351,0.0002105831,0.0001935314,0.0001319661,0.0002026037,0.0003768284,0.000193018,0.0001351981,0.0007597003],"category_scores_gemma":[0.0001683573,0.0002084541,0.00008378181,0.0000799566,0.0002547143,0.0002427044,0.0003643012,0.0002770667,0.0003178659],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004397742,"about_ca_system_score_gemma":0.0002203047,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005816421,"about_ca_topic_score_gemma":0.001754547,"domain_scores_codex":[0.9998765,0.00002731977,0.000009849244,0.00002198323,0.00004143445,0.00002280659],"domain_scores_gemma":[0.9999411,0.000009517759,0.00001693601,0.000004631243,0.000004448055,0.00002341446],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006238285,0.000005400132,0.0002776107,0.00001793346,0.000001938639,0.00003904664,0.00001212099,0.00006214947,0.9980966,0.0002910928,0.00001351206,0.001120252],"study_design_scores_gemma":[0.00001870849,0.0000753365,0.00692315,0.000008890665,0.000008127284,0.000149354,0.00003087525,0.002118344,0.9873772,0.0001580775,0.003128204,0.000003692309],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988664,0.003961884,0.004259076,0.0001255097,0.00002106063,0.00001367226,0.0001053755,0.00003839951,0.002810987],"genre_scores_gemma":[0.9935289,0.001111225,0.002227167,0.00002162038,0.000004677572,0.00001577544,0.000104133,0.000008694961,0.002977766],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007597003,"threshold_uncertainty_score":0.003190815,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02859379185949744,"score_gpt":0.2580592481677103,"score_spread":0.2294654563082129,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}