{"id":"W2088266974","doi":"10.1158/0008-5472.sabcs12-pd03-02","title":"Abstract PD03-02: Evidence for the anti-cancer action of metformin mediated via tumor AMPK, Akt and Ki67, in a preoperative window of opportunity trial","year":2012,"lang":"en","type":"article","venue":"Cancer Research","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Mount Sinai Hospital","funders":"","keywords":"Metformin; Medicine; Breast cancer; AMPK; Internal medicine; Cancer; Oncology; Endocrinology; Insulin; Protein kinase A; Kinase; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001231544,0.0007428398,0.001515729,0.0002436792,0.0002782651,0.0009709834,0.0006208298,0.00100015,0.006186156],"category_scores_gemma":[0.001285804,0.0002563875,0.001142252,0.0004011333,0.0005667444,0.000481225,0.0002878049,0.001877563,0.0005449436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004363097,"about_ca_system_score_gemma":0.001006701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004658336,"about_ca_topic_score_gemma":0.0008867435,"domain_scores_codex":[0.9995089,0.0002965974,0.0000458916,0.00004584506,0.00004470889,0.00005814136],"domain_scores_gemma":[0.9990778,0.0002695594,0.0002036335,0.00006808921,0.00004616052,0.00033467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9734126,0.002550493,0.001347495,0.0003638525,0.0005468914,0.00003807236,0.00001576337,0.0001216154,0.002900626,0.00006956015,0.0007585167,0.01787446],"study_design_scores_gemma":[0.8461214,0.1358491,0.01244275,0.00009584061,0.001168019,0.0001135314,0.00003433152,0.000675534,0.002022437,0.000227065,0.001225435,0.00002461865],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990137,0.005102429,0.0003781048,0.0009802887,0.0002918008,0.0004705267,0.0008084603,0.00008279904,0.001748541],"genre_scores_gemma":[0.9944555,0.001728239,0.0005383301,0.0007245153,0.0002318035,0.0005003801,0.0006346328,0.0000142564,0.001172501],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006186156,"threshold_uncertainty_score":0.02069473,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2830740800016184,"score_gpt":0.4801392701035769,"score_spread":0.1970651901019585,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}