{"id":"W2088277236","doi":"10.1002/ana.21315","title":"Adenosine A <sub>2A</sub> receptor antagonist istradefylline (KW‐6002) reduces “off” time in Parkinson's disease: A double‐blind, randomized, multicenter clinical trial (6002‐US‐005)","year":2008,"lang":"en","type":"article","venue":"Annals of Neurology","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":350,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Medicine; Placebo; Randomization; Randomized controlled trial; Adverse effect; Clinical Global Impression; Clinical endpoint; Confidence interval; Clinical trial; Anesthesia; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00101577,0.0004309879,0.001138897,0.000176121,0.0001094521,0.00002002056,0.0004671624,0.0005022087,0.00009055668],"category_scores_gemma":[0.0006452826,0.0003958177,0.0006463678,0.0002188904,0.0007757847,0.00001813601,0.0001952897,0.0004694089,0.00005220746],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004203024,"about_ca_system_score_gemma":0.0001960818,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002692625,"about_ca_topic_score_gemma":0.000006640082,"domain_scores_codex":[0.9957556,0.0008755489,0.001467841,0.0009579883,0.000283307,0.0006597682],"domain_scores_gemma":[0.9981267,0.0003100254,0.0005715314,0.0005034468,0.0001743372,0.0003139756],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.88143,0.001293308,0.002359993,0.00002792191,0.0002117074,0.0002167588,0.00003757732,0.0001641569,0.07167307,0.00001172354,0.04207164,0.0005021786],"study_design_scores_gemma":[0.6738876,0.003517224,0.002173994,0.00005247059,0.0001649634,0.0001221291,0.000007536545,0.0006409078,0.1890097,0.00005214625,0.1295997,0.0007716143],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862587,0.006196716,0.00003162902,0.005719921,0.000493102,0.00106069,0.00008069802,0.00002837529,0.0001301537],"genre_scores_gemma":[0.9830151,0.01110186,0.00008191462,0.003231215,0.001785021,0.0001140023,0.0003761652,0.0000606091,0.0002341096],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2075424,"threshold_uncertainty_score":0.9998494,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06761578781320707,"score_gpt":0.3404442775767428,"score_spread":0.2728284897635357,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}