{"id":"W2088277236","doi":"10.1002/ana.21315","title":"Adenosine A <sub>2A</sub> receptor antagonist istradefylline (KW‐6002) reduces “off” time in Parkinson's disease: A double‐blind, randomized, multicenter clinical trial (6002‐US‐005)","year":2008,"lang":"en","type":"article","venue":"Annals of Neurology","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":350,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Medicine; Placebo; Randomization; Randomized controlled trial; Adverse effect; Clinical Global Impression; Clinical endpoint; Confidence interval; Clinical trial; Anesthesia; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009148346,0.00118334,0.001823422,0.0002908561,0.000305932,0.0004644837,0.0005323094,0.001053143,0.003527702],"category_scores_gemma":[0.0006536716,0.0004218549,0.0006161542,0.0002499645,0.0006140981,0.0003947929,0.000157807,0.001177271,0.0005998908],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003136804,"about_ca_system_score_gemma":0.0005663097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005121719,"about_ca_topic_score_gemma":0.001200032,"domain_scores_codex":[0.9996586,0.0001777064,0.0000342745,0.00005159412,0.00003097571,0.00004686708],"domain_scores_gemma":[0.999605,0.0000804948,0.0001135348,0.00002900102,0.00003559676,0.0001363884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9312893,0.0134464,0.001381806,0.0005496852,0.0006689975,0.0000438349,0.0000544289,0.0002280761,0.01980356,0.00004896054,0.0006871426,0.03179788],"study_design_scores_gemma":[0.8242722,0.1638248,0.007318758,0.00003296844,0.0003875137,0.0000803494,0.00002061641,0.0004613871,0.003002355,0.00003788382,0.0005478878,0.00001321226],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959036,0.001795786,0.0002311077,0.000114273,0.00009491762,0.0008197966,0.0002873794,0.00006608768,0.000687039],"genre_scores_gemma":[0.9926997,0.001817744,0.001044806,0.0003815457,0.0002973457,0.001477237,0.0007377141,0.00001565882,0.001528236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003527702,"threshold_uncertainty_score":0.01180136,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06761578781320707,"score_gpt":0.3404442775767428,"score_spread":0.2728284897635357,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}