{"id":"W2088391278","doi":"10.1007/s00232-005-0792-1","title":"Recent Progress in Understanding the Mechanism of P-Glycoprotein-mediated Drug Efflux","year":2005,"lang":"en","type":"review","venue":"The Journal of Membrane Biology","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":209,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"ATP-binding cassette transporter; Efflux; P-glycoprotein; Transmembrane protein; Linker; Transmembrane domain; Glycoprotein; Chemistry; Mechanism (biology); Cyclic nucleotide-binding domain; Multiple drug resistance; Transporter; Drug; Biology; Biochemistry; Nucleotide; Cell biology; Drug resistance; Amino acid; Pharmacology; Gene; Genetics; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003463684,0.0003860686,0.002335755,0.0003717607,0.00007258305,0.000005799254,0.0006549452,0.0003896399,0.0001975987],"category_scores_gemma":[0.00008317146,0.0001595337,0.0005109917,0.0005171428,0.0003377128,0.00003240489,0.0000440998,0.001265259,0.00001094724],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003026306,"about_ca_system_score_gemma":0.0006341193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003936036,"about_ca_topic_score_gemma":0.00003724442,"domain_scores_codex":[0.9967343,0.0007116223,0.001607175,0.0001789258,0.0003721371,0.0003958109],"domain_scores_gemma":[0.9970934,0.0005699383,0.001677259,0.0004145909,0.0001412758,0.0001035654],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001459513,0.0005698709,0.00002845667,0.01282494,0.001716392,0.0002517246,0.00152779,0.000004106072,0.0004923729,0.01085935,0.000255716,0.9700097],"study_design_scores_gemma":[0.002573055,0.0006523773,0.0000117238,0.02175027,0.002949198,0.001369436,0.0006670275,0.00000706323,0.0003705906,0.0016982,0.9676407,0.0003103405],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002453048,0.9955926,0.0002270813,0.001768074,0.0007031167,0.001201209,0.00001781184,0.00001099653,0.000233839],"genre_scores_gemma":[0.004625377,0.99449,0.0001150276,0.00008645578,0.0004417968,0.0000149274,0.00002592222,0.00004885362,0.0001516371],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9696994,"threshold_uncertainty_score":0.6505595,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05906244447874416,"score_gpt":0.330897662468623,"score_spread":0.2718352179898789,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}