{"id":"W2088404098","doi":"10.1212/wnl.0b013e3181bf9907","title":"<i>MGMT</i> METHYLATION IS A PROGNOSTIC BIOMARKER IN ELDERLY PATIENTS WITH NEWLY DIAGNOSED GLIOBLASTOMA","year":2009,"lang":"en","type":"article","venue":"Neurology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Takeda Oncology; Genentech; National Institutes of Health; National Cancer Institute; Royal College of Physicians and Surgeons of Canada; Vertex Pharmaceuticals; Enzon Pharmaceuticals; Acceleron; Alnylam Pharmaceuticals; Exelixis; Biogen; Massachusetts General Hospital; AstraZeneca; Fidelity Foundation; Pfizer","keywords":"Glioblastoma; Biomarker; Oncology; Methylation; Medicine; Internal medicine; Cancer research; Biology; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002229956,0.0002323784,0.0002995218,0.0007094033,0.000308378,0.0003341164,0.0001860671,0.0003896143,0.0008944072],"category_scores_gemma":[0.001022784,0.0001309601,0.0001556763,0.0006989177,0.0001553878,0.0003419507,0.0002135312,0.0002227886,0.0002508063],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002357331,"about_ca_system_score_gemma":0.0001805909,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002885797,"about_ca_topic_score_gemma":0.004060847,"domain_scores_codex":[0.999902,0.00001648493,0.00001434898,0.00001983333,0.00002569753,0.00002155986],"domain_scores_gemma":[0.9996678,0.00004177711,0.0001611262,0.00001268975,0.00004125611,0.00007545375],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000191257,0.00001334911,0.9960606,0.000007157886,0.00002332937,0.0005709127,0.00003154851,0.00003738476,0.00062683,0.00001014267,0.0001781899,0.00224923],"study_design_scores_gemma":[0.000006358126,0.0001097739,0.9972957,0.000007552434,0.00004847778,0.001435772,0.00009818011,0.0003603333,0.0001790169,0.00004111443,0.0004129666,0.000004744866],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981174,0.0008929594,0.00004820664,0.0001397856,0.00001708595,0.000005756968,0.0001911095,0.000007111022,0.0005805289],"genre_scores_gemma":[0.9993804,0.0002195528,0.00005218582,0.00004039398,0.00002290261,0.000002878817,0.0001554773,0.000001278758,0.0001250106],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002885797,"threshold_uncertainty_score":0.00573802,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009195241673209373,"score_gpt":0.2422107512987836,"score_spread":0.2330155096255742,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}