{"id":"W2088410504","doi":"10.1002/adma.200501043","title":"Biofunctionalized pH‐Responsive Microgels for Cancer Cell Targeting: Rational Design","year":2005,"lang":"en","type":"article","venue":"Advanced Materials","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":228,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"HeLa; Endocytosis; Materials science; Doxorubicin; Rational design; Drug delivery; Cancer cell; Cytotoxicity; Intracellular; Receptor-mediated endocytosis; Biophysics; Nanotechnology; Targeted drug delivery; Cell; Cell biology; Cancer; Chemistry; Biochemistry; Biology; In vitro; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001052193,0.0002664119,0.0003722136,0.00005662823,0.0002463823,0.0001240952,0.0002395959,0.00009230759,0.006442746],"category_scores_gemma":[0.0003149766,0.0002515615,0.00007830965,0.00009782277,0.00008882169,0.0007391432,0.00005858313,0.00003477116,0.00056756],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003116806,"about_ca_system_score_gemma":0.00030787,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003647801,"about_ca_topic_score_gemma":0.00001343266,"domain_scores_codex":[0.9977578,0.0002205161,0.0006052675,0.0005316063,0.0003510732,0.0005337315],"domain_scores_gemma":[0.9982938,0.0005233052,0.0003114729,0.0002605892,0.0004911786,0.0001196814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001675651,0.0001085976,0.0000031739,0.00003596129,0.000009673494,0.000001882314,0.00008684372,0.007193693,0.9848814,0.0002830373,0.005255817,0.0004642489],"study_design_scores_gemma":[0.002012563,0.00009658585,0.00001185014,0.00002658437,0.00003350549,0.000002832201,0.00004332518,0.00008957075,0.9547223,0.000764902,0.04188775,0.0003082016],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9722043,0.001496107,0.02161259,0.0007781546,0.001688404,0.001221235,0.000742488,0.0002037681,0.00005299517],"genre_scores_gemma":[0.8226535,0.0001436917,0.1723844,0.001353607,0.000868731,0.001269088,0.00007891549,0.00007179674,0.001176211],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1507718,"threshold_uncertainty_score":0.9999937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01882782271334766,"score_gpt":0.2721417029293641,"score_spread":0.2533138802160165,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}