{"id":"W2088453708","doi":"10.1097/00000542-200204000-00019","title":"Interaction of Morphine, Fentanyl, Sufentanil, Alfentanil, and Loperamide with the Efflux Drug Transporter P-glycoprotein","year":2002,"lang":"en","type":"article","venue":"Anesthesiology","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":215,"is_retracted":false,"has_abstract":true,"ca_institutions":"Columbia College","funders":"National Institute of General Medical Sciences","keywords":"P-glycoprotein; Pharmacology; Loperamide; Medicine; Alfentanil; Transcellular; Sufentanil; Paracellular transport; Morphine; Mediated transport; Fentanyl; Internal medicine; Biochemistry; Chemistry; Diarrhea; Permeability (electromagnetism)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001717324,0.0002772919,0.0002990841,0.0001312341,0.0001490082,0.0003105824,0.0001441099,0.0002516703,0.0005601916],"category_scores_gemma":[0.000288432,0.000118561,0.0003112826,0.0001098934,0.0001308681,0.0002752988,0.0001395374,0.0002488529,0.0001347934],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002669974,"about_ca_system_score_gemma":0.0001768782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008502614,"about_ca_topic_score_gemma":0.0007419816,"domain_scores_codex":[0.999806,0.00006359578,0.00001052492,0.0000237152,0.0000496515,0.00004658521],"domain_scores_gemma":[0.999916,0.00002969369,0.00002330956,0.000006639809,0.00001381053,0.00001048683],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001037386,0.0001477627,0.005086367,0.0002022655,0.00009999926,0.0003722866,0.0000612819,0.0003858401,0.9803623,0.0002089328,0.0002779093,0.01175754],"study_design_scores_gemma":[0.00007360362,0.004459798,0.05382778,0.00002388496,0.0001768394,0.002017477,0.0001189989,0.008717238,0.9256781,0.000109266,0.004772272,0.00002469248],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942444,0.004168237,0.0008046515,0.0001082467,0.00001684009,0.00001436976,0.00006889391,0.00001646084,0.0005579373],"genre_scores_gemma":[0.9969432,0.001756532,0.0006897504,0.00003650819,0.00001512548,0.00001377846,0.0001126922,0.000003249371,0.0004291728],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008502614,"threshold_uncertainty_score":0.001937211,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01101062674450504,"score_gpt":0.2095948011260099,"score_spread":0.1985841743815049,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}