{"id":"W2088494127","doi":"10.1038/cr.2013.36","title":"Caspase-mediated cleavage of C53/LZAP protein causes abnormal microtubule bundling and rupture of the nuclear envelope","year":2013,"lang":"en","type":"article","venue":"Cell Research","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute for Biological Sciences","funders":"National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; National Institutes of Health; University of Texas Southwestern Medical Center; Bunning Food Allergy Institute, Ann and Robert H. Lurie Children's Hospital of Chicago; Northwestern University","keywords":"Cell biology; Lamin; Biology; Nuclear lamina; Caspase; Apoptosis; Chromatin; Nuclear protein; Cytoplasm; Cleavage (geology); Fragmentation (computing); Cell nucleus; DNA damage; Programmed cell death; Nucleus; DNA; Biochemistry; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002433428,0.000456819,0.0002911696,0.0004307377,0.0002614307,0.0003506776,0.0003379587,0.0006609953,0.001859277],"category_scores_gemma":[0.0003301471,0.0002310661,0.0003978621,0.0002265685,0.0004567492,0.0004209797,0.0002494905,0.001077123,0.0006330506],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006930065,"about_ca_system_score_gemma":0.0002165112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006980916,"about_ca_topic_score_gemma":0.0004723377,"domain_scores_codex":[0.9997585,0.00003657485,0.00003481872,0.00004239849,0.00006188064,0.00006578823],"domain_scores_gemma":[0.9995826,0.00009915311,0.0001188382,0.00007421093,0.00003120179,0.00009402923],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002951248,0.00004316831,0.0001649244,0.00002593373,0.00001101114,0.0007462914,0.00001261182,0.00008723158,0.9976746,0.0002127047,0.00007425465,0.0006521501],"study_design_scores_gemma":[0.00003673198,0.00010573,0.001664647,0.000002357667,0.00001014468,0.001378657,0.00001701108,0.001053972,0.9951196,0.00008381663,0.0005227404,0.000004531049],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952297,0.0006207823,0.002623965,0.0001938878,0.0000512356,0.00002220323,0.000334527,0.00009322711,0.0008303444],"genre_scores_gemma":[0.9975611,0.0001678688,0.0009044254,0.00003104241,0.000007929237,0.00001282886,0.0003065097,0.00001471113,0.0009935988],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001859277,"threshold_uncertainty_score":0.006219923,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01395367993745469,"score_gpt":0.2481634127067537,"score_spread":0.234209732769299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}