{"id":"W2088494127","doi":"10.1038/cr.2013.36","title":"Caspase-mediated cleavage of C53/LZAP protein causes abnormal microtubule bundling and rupture of the nuclear envelope","year":2013,"lang":"en","type":"article","venue":"Cell Research","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute for Biological Sciences","funders":"National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; National Institutes of Health; University of Texas Southwestern Medical Center; Bunning Food Allergy Institute, Ann and Robert H. Lurie Children's Hospital of Chicago; Northwestern University","keywords":"Cell biology; Lamin; Biology; Nuclear lamina; Caspase; Apoptosis; Chromatin; Nuclear protein; Cytoplasm; Cleavage (geology); Fragmentation (computing); Cell nucleus; DNA damage; Programmed cell death; Nucleus; DNA; Biochemistry; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002398112,0.00008229633,0.0001010654,0.00004539545,0.0001068633,0.00002026666,0.0001902628,0.0001540158,0.0001023751],"category_scores_gemma":[0.00008971657,0.00005823507,0.00004076675,0.0001359671,0.0002564595,0.0000055714,0.0002418186,0.0002246486,0.00001833115],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007430538,"about_ca_system_score_gemma":0.00005998258,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002810263,"about_ca_topic_score_gemma":0.00002374778,"domain_scores_codex":[0.9991248,0.0001125751,0.0001476475,0.000190457,0.0002021935,0.0002223911],"domain_scores_gemma":[0.9993698,0.00002036897,0.00005733344,0.0002988425,0.0001955004,0.00005817912],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005002056,0.00002719957,0.001207352,0.0000905016,0.00001378481,8.178463e-7,0.00012226,0.000001090972,0.9943635,0.00004595784,0.003546355,0.0005311102],"study_design_scores_gemma":[0.0002717451,0.0002341285,0.01446182,0.00002168278,0.000004570727,0.000004682466,0.0002938566,0.00001907273,0.9705774,0.00004680197,0.01399393,0.00007035981],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954427,0.0004014311,0.000004355615,0.0000903563,0.00004171059,0.0003891033,0.000009984501,0.00000368556,0.003616712],"genre_scores_gemma":[0.9985253,0.00009305866,0.000169453,0.00004037471,0.00007432402,0.000008574817,0.00001118103,0.00001995662,0.001057765],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0237862,"threshold_uncertainty_score":0.2374757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01395367993745469,"score_gpt":0.2481634127067537,"score_spread":0.234209732769299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}