{"id":"W2088503826","doi":"10.1242/jcs.036905","title":"Identification of GW182 and its novel isoform TNGW1 as translational repressors in Ago2-mediated silencing","year":2008,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; University of Alberta; National Institute of Dental and Craniofacial Research; Fondation pour la Recherche Médicale; Arthritis Society; Canadian Institutes of Health Research; Andrew J. Semesco Foundation; Friedrich Miescher Institute for Biomedical Research","keywords":"Biology; Gene silencing; Argonaute; Repressor; RasiRNA; RNA-induced silencing complex; P-bodies; Trans-acting siRNA; Small interfering RNA; Messenger RNA; RNA; Genetics; Cell biology; Molecular biology; Gene expression; Gene; Translation (biology)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008115284,0.00004163918,0.00007698157,0.0001260483,0.00006525309,0.0000108985,0.0001752278,0.00003347556,0.000004700981],"category_scores_gemma":[0.00030254,0.00003533273,0.00002751378,0.0002215749,0.0001399061,0.00002981772,0.00002442569,0.00007865866,8.206403e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001063597,"about_ca_system_score_gemma":0.0002753183,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001044859,"about_ca_topic_score_gemma":0.000005107469,"domain_scores_codex":[0.9991038,0.00001221112,0.0002923366,0.0001133371,0.0003482095,0.0001300551],"domain_scores_gemma":[0.9994313,0.00002007253,0.0001889715,0.00007038696,0.0002111764,0.00007810921],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003383309,0.00003280008,0.002454185,0.00000788163,0.000001759011,0.000003384681,0.0001759085,0.0003092177,0.9968085,0.0000128645,0.0000101854,0.0001494755],"study_design_scores_gemma":[0.0003628151,0.0001141247,0.04134009,0.0000154816,0.000001541857,0.00007076169,0.00007679751,0.002314239,0.9556017,0.00002098143,0.000043106,0.00003837196],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986283,0.0004278852,0.0005151196,0.0000883722,0.00003278499,0.00004451104,0.000001891937,5.461032e-7,0.0002605708],"genre_scores_gemma":[0.9990451,0.0004264543,0.000261721,0.00001728172,0.00002742599,4.713314e-7,8.941719e-7,0.000002353765,0.0002182363],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04120682,"threshold_uncertainty_score":0.1440827,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0165670438825834,"score_gpt":0.2817762109683869,"score_spread":0.2652091670858035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}