{"id":"W2088509045","doi":"10.1159/000345203","title":"The Genetics of Susceptibility to Variant Creutzfeldt-Jakob Disease","year":2013,"lang":"en","type":"review","venue":"Public Health Genomics","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Agency of Canada","funders":"","keywords":"Bovine spongiform encephalopathy; PRNP; Disease; Incubation period; Genotype; Genetic predisposition; Biology; Infectious agent; Transmissible spongiform encephalopathy; Population; Genetics; Virology; Medicine; Prion protein; Gene; Environmental health; Scrapie; Incubation; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001489903,0.0003972714,0.0008310416,0.0000783327,0.0002922039,0.0001332022,0.001023416,0.0002513077,0.00004023772],"category_scores_gemma":[0.0005813292,0.0002923407,0.0004883728,0.0002132761,0.0001050875,0.000003494567,0.0006505565,0.0002200169,0.00005052474],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001882286,"about_ca_system_score_gemma":0.00489552,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005477738,"about_ca_topic_score_gemma":0.00003481146,"domain_scores_codex":[0.9968312,0.0004281259,0.001063238,0.0006801159,0.0002222814,0.0007750479],"domain_scores_gemma":[0.9962496,0.00008186402,0.0006039625,0.001621412,0.0001987309,0.001244396],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000009285424,0.00005461029,0.000008633786,0.003658672,0.00008995991,7.926875e-7,0.00001696696,0.000003369426,0.00001197341,0.0002667793,0.003172355,0.9927066],"study_design_scores_gemma":[0.00008197949,0.0001252647,0.00003338815,0.0002508092,0.0000579545,0.000004260143,0.00001607218,0.00001119162,0.00000302852,0.00008575128,0.9990525,0.0002777595],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001596016,0.9942433,0.001617528,0.00136426,0.0003900295,0.001716887,0.0004397549,0.00001257018,0.00005611005],"genre_scores_gemma":[0.00009969683,0.9965294,0.001148618,0.0007089792,0.0004987604,0.0003216314,0.0003970135,0.00007405211,0.000221872],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9958802,"threshold_uncertainty_score":0.9999529,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.082444240108832,"score_gpt":0.3643416596062634,"score_spread":0.2818974194974314,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}