{"id":"W2088509045","doi":"10.1159/000345203","title":"The Genetics of Susceptibility to Variant Creutzfeldt-Jakob Disease","year":2013,"lang":"en","type":"review","venue":"Public Health Genomics","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Agency of Canada","funders":"","keywords":"Bovine spongiform encephalopathy; PRNP; Disease; Incubation period; Genotype; Genetic predisposition; Biology; Infectious agent; Transmissible spongiform encephalopathy; Population; Genetics; Virology; Medicine; Prion protein; Gene; Environmental health; Scrapie; Incubation; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003909188,0.0005830853,0.001081493,0.001876069,0.000194368,0.000677806,0.0005417831,0.0008450067,0.002441437],"category_scores_gemma":[0.0006560538,0.0001899545,0.0002839426,0.00158465,0.0003861047,0.000666661,0.0004822433,0.0008410693,0.0013768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005072387,"about_ca_system_score_gemma":0.0008538353,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001344423,"about_ca_topic_score_gemma":0.001774459,"domain_scores_codex":[0.999878,0.00002087906,0.00001925855,0.00002362931,0.00004477201,0.00001324488],"domain_scores_gemma":[0.9998065,0.00008548143,0.00003467273,0.000004738547,0.0000458417,0.00002279104],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006958153,0.00004177753,0.0004975511,0.009082329,0.00007832802,0.0004059318,0.00006020194,0.000243183,0.001321125,0.00201806,0.02276754,0.9634145],"study_design_scores_gemma":[0.00002427675,0.00009071502,0.004516433,0.004583881,0.0001638177,0.005205532,0.0001025102,0.00009271989,0.0005088469,0.002526535,0.9821599,0.00002465741],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001760173,0.9986206,0.00008308308,0.000243162,0.00008408353,0.000002059812,0.00001631036,0.000005379573,0.0007692805],"genre_scores_gemma":[0.000789281,0.998601,0.00008779737,0.0000746624,0.00008594729,0.000002717815,0.00002271058,8.090888e-7,0.0003350805],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002441437,"threshold_uncertainty_score":0.008167446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.082444240108832,"score_gpt":0.3643416596062634,"score_spread":0.2818974194974314,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}