{"id":"W2088515849","doi":"10.1016/j.immuni.2006.11.009","title":"Chromosome Transfer Activates and Delineates a Locus Control Region for Perforin","year":2007,"lang":"en","type":"article","venue":"Immunity","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":39,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"National Institutes of Health; Canada Research Chairs; Sylvester Comprehensive Cancer Center, University of Miami Health Systems; National Institute of Allergy and Infectious Diseases; Dr. John T. MacDonald Foundation","keywords":"Biology; Locus (genetics); Perforin; Locus control region; Transgene; Gene; Genetics; CTL*; Molecular biology; Transcription (linguistics); Gene silencing; Gene expression; Promoter; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002080707,0.0005895419,0.0003699097,0.0008224456,0.0003328752,0.0007185709,0.0005881327,0.0007486484,0.004252446],"category_scores_gemma":[0.0004250833,0.0005403096,0.0005106751,0.0003407104,0.000847687,0.000412749,0.0009266108,0.001684708,0.001282121],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007161682,"about_ca_system_score_gemma":0.0003370651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009418686,"about_ca_topic_score_gemma":0.001316544,"domain_scores_codex":[0.999671,0.00003694971,0.00001886544,0.0001022608,0.00006346088,0.0001074583],"domain_scores_gemma":[0.9993089,0.0003695693,0.0001328768,0.00007786366,0.00002586921,0.00008492937],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001548649,0.0000266224,0.0001380523,0.00001159013,0.000004751452,0.00009308469,0.0000264364,0.00005657153,0.99808,0.0004708078,0.0000203175,0.0009168425],"study_design_scores_gemma":[0.00009759616,0.0002675567,0.01533737,0.00001605688,0.00003378,0.0006297908,0.0001216519,0.001099096,0.9796396,0.0004655919,0.002276539,0.0000153379],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9794037,0.0008394432,0.01373772,0.0001808837,0.00009447429,0.00006226358,0.0003357083,0.0002111029,0.005134689],"genre_scores_gemma":[0.9925539,0.000247828,0.002497121,0.00008122238,0.00002647541,0.00003487382,0.0005283083,0.0001104192,0.003919787],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004252446,"threshold_uncertainty_score":0.01422578,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01591927813404023,"score_gpt":0.2445904382423386,"score_spread":0.2286711601082983,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}