{"id":"W2088532580","doi":"10.1016/j.cellsig.2014.08.025","title":"Coiled-coil domain containing 3 (CCDC3) represses tumor necrosis factor-α/nuclear factor κB-induced endothelial inflammation","year":2014,"lang":"en","type":"article","venue":"Cellular Signalling","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Tumor necrosis factor alpha; VCAM-1; Paracrine signalling; Autocrine signalling; Gene knockdown; Cell biology; Inflammation; NFKB1; Biology; NF-κB; IκBα; Signal transduction; Chemistry; Cell adhesion molecule; Molecular biology; Endocrinology; Transcription factor; ICAM-1; Immunology; Receptor; Biochemistry; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006232064,0.0004096012,0.0006666078,0.000307238,0.0003382378,0.000208277,0.0003488136,0.0002282388,0.001790945],"category_scores_gemma":[0.0009129703,0.0003900889,0.0003061632,0.0002995,0.0001056135,0.0001994939,0.000177482,0.0007183939,0.0005927993],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001995945,"about_ca_system_score_gemma":0.0001628578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001301271,"about_ca_topic_score_gemma":0.000009134574,"domain_scores_codex":[0.9963582,0.0003307613,0.0007402975,0.000769004,0.001044921,0.0007568867],"domain_scores_gemma":[0.9976931,0.0005154798,0.0003022319,0.0006968442,0.0003231562,0.0004692107],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005103143,0.00006925749,0.0009168429,0.0001851751,0.00007939541,0.0001691511,0.001166037,0.00004865366,0.9903318,0.0002184964,0.0000420015,0.006262892],"study_design_scores_gemma":[0.002384752,0.0005801776,0.0008868537,0.0002987849,0.00005952286,0.00002818737,0.000389337,0.006048717,0.9781227,0.0002058017,0.01056609,0.0004290539],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881335,0.0001128869,0.007261385,0.0002421936,0.0002208493,0.0006898237,0.00001482514,0.0002716244,0.003052915],"genre_scores_gemma":[0.996528,0.00002843329,0.001682951,0.0002201042,0.0007487683,0.00003253964,0.00006145085,0.0001505127,0.0005472246],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01220906,"threshold_uncertainty_score":0.9998551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02981314211710083,"score_gpt":0.268887791602525,"score_spread":0.2390746494854241,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}