{"id":"W2088538523","doi":"10.1038/nsmb.2306","title":"PARP pairs up to PARsylate","year":2012,"lang":"en","type":"letter","venue":"Nature Structural & Molecular Biology","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Poly ADP ribose polymerase; PARP1; Polymerase; Chemistry; DNA; Biophysics; Cell biology; Biochemistry; Molecular biology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.0001386511,0.0007427736,0.001026756,0.0003459841,0.00008941373,0.0000228351,0.000407194,0.005024603,0.001196785],"category_scores_gemma":[0.0001162411,0.0005844518,0.0004606606,0.0003433259,0.0002151524,0.00003873555,0.0001305624,0.00622725,0.0002302784],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002831654,"about_ca_system_score_gemma":0.0001596995,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002436996,"about_ca_topic_score_gemma":0.000001999835,"domain_scores_codex":[0.9967748,0.0002765775,0.0004953263,0.0009443944,0.0004082674,0.001100647],"domain_scores_gemma":[0.9981727,0.00006086711,0.0002475585,0.0009837688,0.0002522225,0.0002828664],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002029456,0.000003704951,0.0002766428,0.0001193456,0.0004331575,0.0005501892,0.00009300042,0.000001361275,0.0698079,0.0006591288,0.9243529,0.003499659],"study_design_scores_gemma":[0.001120271,0.0003148455,0.0007683724,0.0001123575,0.0002054201,0.0006985801,0.000004601463,0.00000206337,0.02419841,0.003423254,0.9685081,0.0006437355],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.02923037,0.01050678,0.0005007284,0.946751,0.009264825,0.001502266,0.0004340406,0.0002967981,0.001513172],"genre_scores_gemma":[0.197174,0.00004322816,0.001311013,0.7902502,0.007004954,0.00009250495,0.002510146,0.0001325964,0.00148141],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.1679436,"threshold_uncertainty_score":0.9997163,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.011736585762756,"score_gpt":0.3508104166436788,"score_spread":0.3390738308809229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}