{"id":"W2088538523","doi":"10.1038/nsmb.2306","title":"PARP pairs up to PARsylate","year":2012,"lang":"en","type":"letter","venue":"Nature Structural & Molecular Biology","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Poly ADP ribose polymerase; PARP1; Polymerase; Chemistry; DNA; Biophysics; Cell biology; Biochemistry; Molecular biology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001021328,0.0008126737,0.0009466065,0.0003428315,0.001879246,0.00248314,0.0009601146,0.01306385,0.01764519],"category_scores_gemma":[0.005604822,0.0005528177,0.001022498,0.0002876461,0.001170048,0.002225325,0.001924245,0.01495983,0.014603],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001695213,"about_ca_system_score_gemma":0.0007652577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005331166,"about_ca_topic_score_gemma":0.0009453605,"domain_scores_codex":[0.9988284,0.0002525791,0.0001013684,0.000186195,0.0003864119,0.0002451045],"domain_scores_gemma":[0.9990694,0.0003616781,0.0001088517,0.0001206674,0.0001267147,0.000212755],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000844691,0.000137142,0.0007359997,0.0002191886,0.00007370888,0.008458046,0.0001912264,0.0004940637,0.01009627,0.02841267,0.8847565,0.06558051],"study_design_scores_gemma":[0.000278276,0.0002549759,0.0004602606,0.00006676622,0.0000387973,0.004416132,0.0001477807,0.0005594454,0.01717971,0.02730986,0.9492365,0.00005156481],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.006118007,0.00969342,0.003349799,0.8750956,0.05531603,0.00007507449,0.0003752463,0.0005543595,0.04942248],"genre_scores_gemma":[0.1117583,0.008264302,0.003194193,0.7137359,0.04071762,0.0002318088,0.0005509363,0.0001776894,0.1213692],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01764519,"threshold_uncertainty_score":0.05902898,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.011736585762756,"score_gpt":0.3508104166436788,"score_spread":0.3390738308809229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}